Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 比较基因组学

	Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations
	Shi H 1; Zhong H 2; Peng Y 1; Dong YL 3; Qi XB 1; Zhang F 4; Liu LF 5; Tan SJ 3; Ma RZ 2; Xiao CJ 3
刊名	BMC BIOLOGY
	2008
卷号	6 期号:X 页码:e45
ISSN号	1741-7007
通讯作者	sub@mail.kiz.ac.cn
合作状况	其它
英文摘要	Background: The phylogeography of the Y chromosome in Asia previously suggested that modern humans of African origin initially settled in mainland southern East Asia, and about 25,000 30,000 years ago, migrated northward, spreading throughout East Asia. However, the fragmented distribution of one East Asian specific Y chromosome lineage (D-M174), which is found at high frequencies only in Tibet, Japan and the Andaman Islands, is inconsistent with this scenario. Results: In this study, we collected more than 5,000 male samples from 73 East Asian populations and reconstructed the phylogeography of the D-M174 lineage. Our results suggest that D-M174 represents an extremely ancient lineage of modern humans in East Asia, and a deep divergence was observed between northern and southern populations. Conclusion: We proposed that D-M174 has a southern origin and its northward expansion occurred about 60,000 years ago, predating the northward migration of other major East Asian lineages. The Neolithic expansion of Han culture and the last glacial maximum are likely the key factors leading to the current relic distribution of D-M174 in East Asia. The Tibetan and Japanese populations are the admixture of two ancient populations represented by two major East Asian specific Y chromosome lineages, the O and D haplogroups.
收录类别	SCI
资助信息	This study was supported by grants from the National 973 project of China (2006CB701506, 2007CB815705), the Chinese Academy of Sciences (KSCX1-YW-R-34), the National Natural Science Foundation of China (30700445, 30771181, 30370755, 30525028 and 30630013), and the Nat- ural Science Foundation of Yunnan Province of China.
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/2163]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming, PR China 2.Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, PR China 3.Human Genetics Centre, Yunnan University, Kunming, PR China 4.State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai, PR China 5.Huaihua Medical College, Huaihua, Hunan, PR China 6.The Genographic Project, National Geographic Society, Washington, USA
推荐引用方式 GB/T 7714	Shi H,Zhong H,Peng Y,et al. Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations[J]. BMC BIOLOGY,2008,6(X):e45.
APA	Shi H.,Zhong H.,Peng Y.,Dong YL.,Qi XB.,...&Su B[*].(2008).Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations.BMC BIOLOGY,6(X),e45.
MLA	Shi H,et al."Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations".BMC BIOLOGY 6.X(2008):e45.