Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions

CORC > 上海有机化学研究所 > 中国科学院上海有机化学研究所 > 生命有机化学国家重点实验室

	Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions
	Huang HC(黄汉初); Zhang GJ(张国晋); Chen YY(陈以昀)
刊名	Angew. Chem.-Int. Edit.
	2015
卷号	54 期号:27 页码:7872-7876
其他题名	高价碘促进的脱羧炔酮化反应在温和光催化条件下进行
通讯作者	陈以昀
英文摘要	A combination of hypervalent iodine(III) reagents (HIR) and photoredox catalysis with visible light has enabled chemoselective decarboxylative ynonylation to construct ynones, ynamides, and ynoates. This ynonylation occurs effectively under mild reaction conditions at room temperature and on substrates with various sensitive and reactive functional groups. The reaction represents the first HIR/photoredox dual catalysis to form acyl radicals from -ketoacids, followed by an unprecedented acyl radical addition to HIR-bound alkynes. Its efficient construction of an mGlu5 receptor inhibitor under neutral aqueous conditions suggests future visible-light-induced biological applications.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/anie.201502369
语种	英语
WOS记录号	WOS:000356886600024
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39510]
专题	上海有机化学研究所_生命有机化学国家重点实验室
作者单位	中科院上海有机化学研究所, 生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Huang HC,Zhang GJ,Chen YY. Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions[J]. Angew. Chem.-Int. Edit.,2015,54(27):7872-7876.
APA	黄汉初,张国晋,&陈以昀.(2015).Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions.Angew. Chem.-Int. Edit.,54(27),7872-7876.
MLA	黄汉初,et al."Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions".Angew. Chem.-Int. Edit. 54.27(2015):7872-7876.