Role of Achiral Nucleobases in Multicomponent Chiral Self-Assembly: Purine-Triggered Helix and Chirality Transfer

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	Role of Achiral Nucleobases in Multicomponent Chiral Self-Assembly: Purine-Triggered Helix and Chirality Transfer
	Deng, Ming 1,2; Zhang, Li 1; Jiang, Yuqian 3; Liu, Minghua 1,2,3,4
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2016-11-21
卷号	55 期号:48 页码:15062-15066
关键词	chirality transfer circular polarized fluorescence helical structures nucleobases purines
英文摘要	Chiral self-assembly is a basic process in biological systems, where many chiral biomolecules such as amino acids and sugars play important roles. Achiral nucleobases usually covalently bond to saccharides and play a significant role in the formation of the double helix structure. However, it remains unclear how the achiral nucleobases can function in chiral self-assembly without the sugar modification. Herein, we have clarified that purine nucleobases could trigger N-(9-fluorenyl-methox-ycarbonyl) (Fmoc)-protected glutamic acid to self-assemble into helical nanostructures. Moreover, the helical nanostructure could serve as a matrix and transfer the chirality to an achiral fluorescence probe, thioflavin T (ThT). Upon chirality transfer, the ThT showed not only supramolecular chirality but also circular polarized fluorescence (CPL). Without the nucleobase, the self-assembly processes cannot happen, thus providing an example where achiral molecules played an essential role in the expression and transfer of the chirality.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35730]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Lab Nanosyst & Hierarchy Fabricat, Beijing 100190, Peoples R China 4.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China
推荐引用方式 GB/T 7714	Deng, Ming,Zhang, Li,Jiang, Yuqian,et al. Role of Achiral Nucleobases in Multicomponent Chiral Self-Assembly: Purine-Triggered Helix and Chirality Transfer[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(48):15062-15066.
APA	Deng, Ming,Zhang, Li,Jiang, Yuqian,&Liu, Minghua.(2016).Role of Achiral Nucleobases in Multicomponent Chiral Self-Assembly: Purine-Triggered Helix and Chirality Transfer.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(48),15062-15066.
MLA	Deng, Ming,et al."Role of Achiral Nucleobases in Multicomponent Chiral Self-Assembly: Purine-Triggered Helix and Chirality Transfer".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.48(2016):15062-15066.