Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes

	Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes
	Zhang, Xin 1,2; Jin, Bing 1,2; Zheng, Wei 1; Zhang, Nan 1,2; Liu, Xiangjun 1; Bing, Tao 1; Wei, Yongbiao 1; Wang, Fuyi 1; Shangguan, Dihua 1,2
刊名	DYES AND PIGMENTS
	2016-09-01
卷号	132 页码:405-411
关键词	Hypericin G-Quadruplexes DNA Binding model Molecular docking
英文摘要	Hypericin (Hyp) is one of the principal active constituents of a traditional folk medicine, Hypericum (Saint John's wort), and possesses variety biological activities. The interaction of Hyp with DNA may play an important role in biological activity, however only a few investigations were reported on this issue. In this paper, we studied the interaction of Hyp with different DNA forms. Hyp was found to selectively bind parallel DNA G-Quadruplexes (G4) over other DNA forms, such as ss-/ds-DNA, antiparallel G4s and mix type G4s. Binding studies suggest that Hyp bind on G-quartet surface of G4s through end-stacking interaction. These results provide new information for the investigation of action mechanism of Hyp. (C) 2016 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35545]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xin,Jin, Bing,Zheng, Wei,et al. Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes[J]. DYES AND PIGMENTS,2016,132:405-411.
APA	Zhang, Xin.,Jin, Bing.,Zheng, Wei.,Zhang, Nan.,Liu, Xiangjun.,...&Shangguan, Dihua.(2016).Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes.DYES AND PIGMENTS,132,405-411.
MLA	Zhang, Xin,et al."Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes".DYES AND PIGMENTS 132(2016):405-411.