Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand

	Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand
	Ou, Zhize 1; Qian, Yimeng 1; Gao, Yunyan 1; Wang, Yunqing 1; Yang, Guoqiang 2; Li, Yi 3; Jiang, Kaiyue 1; Wang, Xin 1
刊名	RSC ADVANCES
	2016
卷号	6 期号:43 页码:36923-36931
英文摘要	Two novel metal complexes 2-3 (metal = Pd-II, Pt-II) have been synthesized by reacting the corresponding tolylterpyridine complexes and the 4-aminonaphthalimide derivative 1. The interactions of the complexes with duplex DNA and telomeric G-quadruplex DNA have been investigated by UV-Vis spectroscopy and fluorescence spectroscopy. The studies reveal that the complexes 2-3 possess high affinity and reasonable selectivity for telomeric G-quadruplex DNA over duplex DNA. Spectroscopic and molecular docking studies suggest that the complexes 2-3 interact with telomeric G-quadruplex DNA mainly through groove binding. The compounds 1-3 are emissive (Phi(em) > 0.22), making it possible to study the localization of 1-3 in A549 using fluorescence microscopy. The complexes 2-3 are mainly localized in nuclei, while 1 is localized in the nuclei and cytoplasmic region after 0.5 h incubation. The complex 3 inhibits A549 cells selectively over non-cancerous NIH3T3 cells, with higher antitumor activity than 1 and cisplatin.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/36083]
专题	化学研究所_光化学实验室
作者单位	1.Northwestern Polytech Univ, Dept Appl Chem, Sch Sci, Key Lab Space Appl Phys & Chem,Minist Educ, Xian 710072, Peoples R China 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Conves & Optoelect Mat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ou, Zhize,Qian, Yimeng,Gao, Yunyan,et al. Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand[J]. RSC ADVANCES,2016,6(43):36923-36931.
APA	Ou, Zhize.,Qian, Yimeng.,Gao, Yunyan.,Wang, Yunqing.,Yang, Guoqiang.,...&Wang, Xin.(2016).Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand.RSC ADVANCES,6(43),36923-36931.
MLA	Ou, Zhize,et al."Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand".RSC ADVANCES 6.43(2016):36923-36931.