Switching on Supramolecular Catalysis via Cavity Mediation and Electrostatic Regulation | |
Qiao, Yupu1; Zhang, Long2; Li, Jia1; Lin, Wei3; Wang, Zhenqiang1 | |
刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION |
2016-10-04 | |
卷号 | 55期号:41页码:12778-12782 |
关键词 | calixarenes container molecules Knoevenagel condensation supramolecular catalysis tetraalkylammonium |
英文摘要 | Synthetic supercontainers constructed from divalent metal ions, carboxylate linkers, and sulfonylcalix[4]arene-based container precursors exhibit great promise as enzyme mimics that function in organic solvents. The capacity of these artificial hosts to catalyze Knoevenagel condensation can be switched on when the aldehyde substrate possesses a molecular size and shape matching the nanocavity of the supercontainers. In contrast, little reactivity is observed for other aldehydes that do not match the binding pocket. This substrate-dependent catalytic selectivity is attributed to the BrOnsted acidity of the metal-bound water molecules located inside the nanocavity, which is amplified when the size/shape of the aldehyde substrate fits the binding cavity. The electrostatic environment of the binding cavity and the BrOnsted acidity of the supercontainer can be further modulated using tetraalkylammonium-based regulators, leading to higher reactivity for the otherwise unreactive aldehydes. |
收录类别 | SCI |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.iccas.ac.cn/handle/121111/35519] |
专题 | 化学研究所_分子识别与功能实验室 |
作者单位 | 1.Univ South Dakota, Dept Chem, Churchill Haines Labs, 414 East Clark St,Room 115, Vermillion, SD 57069 USA 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China 3.Univ Minnesota, Dept Chem, 207 Pleasant St SE, Minneapolis, MN 55455 USA |
推荐引用方式 GB/T 7714 | Qiao, Yupu,Zhang, Long,Li, Jia,et al. Switching on Supramolecular Catalysis via Cavity Mediation and Electrostatic Regulation[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(41):12778-12782. |
APA | Qiao, Yupu,Zhang, Long,Li, Jia,Lin, Wei,&Wang, Zhenqiang.(2016).Switching on Supramolecular Catalysis via Cavity Mediation and Electrostatic Regulation.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(41),12778-12782. |
MLA | Qiao, Yupu,et al."Switching on Supramolecular Catalysis via Cavity Mediation and Electrostatic Regulation".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.41(2016):12778-12782. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论