BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting

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	BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting
	Huang J(黄洁); Fu H(付寒); Wang ZY(王芷莹); Meng QY(孟庆圆); Liu SM(刘素梅); Wang HR(王赫然); Zheng XF(郑雄飞); Dai JW(戴建武); Zhang ZJ(张智军)
刊名	RSC Advances
	2016
卷号	6 期号:110 页码:108423-108430
ISSN号	2046-2069
通讯作者	戴建武 ; 张智军
产权排序	3
中文摘要	Three-dimensional (3D) bioprinting technology offers the possibility to deliver, in a defined and organized manner, scaffolding materials and living cells, and therefore holds much promise for tissue engineering and regenerative medicine. In this work, we explored the possibility of gelatin/sodium alginate/carboxymethyl chitosan (Gel/SA/CMCS) hydrogel combining with bone mesenchymal stem cells (BMSCs) for 3D bioprinting. Compared to the commonly used 3D bioprinting materials such as gelatin/sodium alginate (Gel/SA) hydrogel, the Gel/SA/CMCS hydrogel we developed shows excellent equilibrium water content, good mechanical properties, antibacterial activity, and a slow degradation rate. With this kind of material, we generated a scaffold with homogenous cell distribution. Cell viability after 3D printing showed that over 85% of the printed cells were viable at 0 and 2 days of culturing. Our work demonstrates the feasibility of mixing Gel/SA/CMCS hydrogel with stem cells for 3D bioprinting.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	MESENCHYMAL STEM-CELLS ; ENGINEERED CARTILAGE CONSTRUCTS ; OSTEOGENIC DIFFERENTIATION ; VALVE CONDUITS ; TISSUE ; ALGINATE ; ORGANIZATION ; FABRICATION ; SCAFFOLDS ; CULTURE
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000389342800036
内容类型	期刊论文
源URL	[http://ir.sia.cn/handle/173321/19478]
专题	沈阳自动化研究所_机器人学研究室
推荐引用方式 GB/T 7714	Huang J,Fu H,Wang ZY,et al. BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting[J]. RSC Advances,2016,6(110):108423-108430.
APA	Huang J.,Fu H.,Wang ZY.,Meng QY.,Liu SM.,...&Zhang ZJ.(2016).BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting.RSC Advances,6(110),108423-108430.
MLA	Huang J,et al."BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting".RSC Advances 6.110(2016):108423-108430.