Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers

	Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers
	Zhang, Xiao-Mei; Guo, Kun; Li, Luo-Hao; Zhang, Sheng; Li, Bang-Jing
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2015
卷号	3 期号:29 页码:6026-6031
关键词	AMPHIPHILIC TRIBLOCK COPOLYMERS IRON-OXIDE NANOPARTICLES GUIDED DRUG-DELIVERY POLYMERIC MICELLES GOLD NANOPARTICLE CANCER WATER VESICLES
通讯作者	Sheng, ZB (reprint author), Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China.
产权排序	1
合作状况	国内
英文摘要	A novel approach has been developed to prepare the magnetic micelles. Polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) are firstly attached on the surface of the magnetic nanoparticle via the host-guest inclusion between ferrocene groups (Fc) and beta-cyclodextrin (beta-CD). Then the resulting MNPs became amphiphilic in water above the LCST of PNIPAM and self-assembled into magnetomicelles with a size of 250 nm. These hybrid micelles show high loading capacity for anticancer drug (DOX) and high saturation magnetization simultaneously. Furthermore, these micelles could disassemble under the effects of oxidant or temperature, providing an opportunity to fine-tune the release properties of the encapsulated drug in response to temperature, H2O2 or pH independently, or a combined effect of multiple stimuli. Taking other advantages of magnetic carriers, such as high sensitivity to the external magnetic field, contrast effect to magnetic resonance, and magnetic hyperthermia, the micelles developed by this study show great potential application in cancer treatment.
学科主题	Materials Science
类目[WOS]	Materials Science, Biomaterials
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/27601]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Zhang, Xiao-Mei,Guo, Kun,Li, Luo-Hao,et al. Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(29):6026-6031.
APA	Zhang, Xiao-Mei,Guo, Kun,Li, Luo-Hao,Zhang, Sheng,&Li, Bang-Jing.(2015).Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers.JOURNAL OF MATERIALS CHEMISTRY B,3(29),6026-6031.
MLA	Zhang, Xiao-Mei,et al."Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers".JOURNAL OF MATERIALS CHEMISTRY B 3.29(2015):6026-6031.