Analysis of sesquiterpene pyridine alkaloids using ESI-MS/MS: The product ion at m/z 310 formed by an ion-dipole intermediate

	Analysis of sesquiterpene pyridine alkaloids using ESI-MS/MS: The product ion at m/z 310 formed by an ion-dipole intermediate
	Cai, Tian; Luo, Ying-Gang; Zhou, Min; Wu, Zhi-Jun; Fang, Dong-Mei; Zhang, Guo-Lin
刊名	INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
	2015
卷号	376 页码:54-57
关键词	ANTI-HIV AGENTS TRIPTERYGIUM-WILFORDII MASS-SPECTROMETRY MAYTENUS-EMARGINATA FRAGMENTATION HYPOGLAUCUM ROOTS
通讯作者	Wu, ZJ (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
产权排序	1
合作状况	国内
英文摘要	Sesquiterpene pyridine alkaloids are a large group of highly oxygenated sesquiterpenoids, attracting attention in the fields of medicine because of their significant biological activities. Three representative sesquiterpene pyridine alkaloids were analyzed by electrospray ionization collision-induced dissociation-tandem mass spectrometry (ESI-CID-MS/MS/MS). In the high mass range, the product ions were formed by the loss of side chains or H2O. In the low mass range, the high-abundance product ions at m/z 206 and 178 were the characteristic ions of the pyridine moiety. Interestingly, the characteristic product ion at m/z 310 was formed through an ion-dipole (ion-neutral) complex. Addition of oxo(phenyl)methylium formed by the loss of the side chain linked to C1 and pyridine moiety produces m/z 310. The product ions at m/z 188 and 105 from m/z 310 support the proposed processes. The product ions were supported by D-labeling experiment. It was found that the formation of the product ion at m/z 310 was related to the position of substituted groups. (C) 2014 Elsevier B.V. All rights reserved.
学科主题	Physics; Spectroscopy
类目[WOS]	Physics, Atomic, Molecular & Chemical ; Spectroscopy
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/27599]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Cai, Tian,Luo, Ying-Gang,Zhou, Min,et al. Analysis of sesquiterpene pyridine alkaloids using ESI-MS/MS: The product ion at m/z 310 formed by an ion-dipole intermediate[J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,2015,376:54-57.
APA	Cai, Tian,Luo, Ying-Gang,Zhou, Min,Wu, Zhi-Jun,Fang, Dong-Mei,&Zhang, Guo-Lin.(2015).Analysis of sesquiterpene pyridine alkaloids using ESI-MS/MS: The product ion at m/z 310 formed by an ion-dipole intermediate.INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,376,54-57.
MLA	Cai, Tian,et al."Analysis of sesquiterpene pyridine alkaloids using ESI-MS/MS: The product ion at m/z 310 formed by an ion-dipole intermediate".INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 376(2015):54-57.