Kosi basin located between the north Nepal and south Tibet of China has abundant water resources. Its recharge sources are glacier meltwater and precipitationin this area. However due to the topographical effects, the distribution of rainfall is uneven in space and time. In order to guarantee the harmonious development ofsocial economy, it’s necessary to evaluate the sustainable utilization of water resources. This paper adopts GIS spatial analysis methods to establish evaluationindexes of water resources sustainable based on DPSIR model, and determine the weights of each evaluation index by utilizing analytic hierarchy process. Theresults show that: (1) the proposed methods can reflect the development level of regional water resources system and its harmonious state with society and economy. (2) The comprehensive evaluation value changes are between 4.0 and 6.9. (3) The sustainable utilization level gradually increases from northwest to southeast. (4) The presented methods can quantitatively evaluate the sustainability of regional water resources.