Preferred formation of the carboxylic acid-pyridine heterosynthon in 2-anilinonicotinic acids

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Preferred formation of the carboxylic acid-pyridine heterosynthon in 2-anilinonicotinic acids
	Chen, Peng 1; Zhang, Zhifei 2; Parkin, Sean 3; Zhou, Panpan 4; Cheng, Kai 5; Li, Conggang 5; Yu, Faquan 1; Long, Sihui 1
刊名	RSC ADVANCES
	2016
卷号	6 期号:84 页码:81101-81109
英文摘要	The carboxylic acid-carboxylic acid homosynthon and carboxylic acid-pyridine heterosynthon are two competing supramolecular synthons in 2-anilinonicotinic acids that possess both carboxylic acid and pyridine functionalities. Previously we demonstrated that carboxylic acid-pyridine heterosynthons can be selectively formed in crystals by chemically introducing bulky functional groups to the aniline ring of the molecules. In this study we show that with the same philosophy, but a different strategy, i.e., adding substituent groups to the nitrogen bridging the two aromatic rings, we can also achieve the preferential formation of the carboxylic acid-pyridine heterosynthon over the carboxylic acid-carboxylic acid homosynthon. This is a new case of how molecular conformation can affect intermolecular interactions and consequent crystal packing.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	HYDROGEN-BOND PATTERNS ; GRAPH-SET ANALYSIS ; SUPRAMOLECULAR SYNTHONS ; PHARMACEUTICAL PHASES ; CRYSTAL-STRUCTURES ; COCRYSTALS ; ISONICOTINAMIDE ; POLYMORPHISM ; COMPETITION ; TERNARY
收录类别	SCI
语种	英语
WOS记录号	WOS:000383903500087
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9597]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Wuhan Inst Technol, Sch Chem Engn & Pharm, Key Lab Green Chem Proc, Minist Educ, 693 Xiongchu Rd, Wuhan 430073, Hubei, Peoples R China 2.North China Univ Sci & Technol, Sch Pharm, Tangshan, Peoples R China 3.Univ Kentucky, Dept Chem, Lexington 40506, KY, Peoples R China 4.Lanzhou Univ, Dept Chem, Lanzhou, Gansu, Peoples R China 5.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Chen, Peng,Zhang, Zhifei,Parkin, Sean,et al. Preferred formation of the carboxylic acid-pyridine heterosynthon in 2-anilinonicotinic acids[J]. RSC ADVANCES,2016,6(84):81101-81109.
APA	Chen, Peng.,Zhang, Zhifei.,Parkin, Sean.,Zhou, Panpan.,Cheng, Kai.,...&Long, Sihui.(2016).Preferred formation of the carboxylic acid-pyridine heterosynthon in 2-anilinonicotinic acids.RSC ADVANCES,6(84),81101-81109.
MLA	Chen, Peng,et al."Preferred formation of the carboxylic acid-pyridine heterosynthon in 2-anilinonicotinic acids".RSC ADVANCES 6.84(2016):81101-81109.