Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic
	Wu, Huifeng1 ; Xu, Lanlan 1,2; Ji, Chenglong1 ; Yu, Deliang 1,2
刊名	FISH & SHELLFISH IMMUNOLOGY
	2016-11-01
卷号	58 页码:514-520
关键词	Mytilus galloprovincialis Cadmium Arsenic Biological effects Proteomics Metabolomics
ISSN号	1050-4648
其他题名	Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic
通讯作者	Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Key Lab Coastal Zone Environm Proc,Yantai Inst Co, Yantai 264003, Peoples R China. Email:hfwu@yic.ac.cn
产权排序	[Wu, Huifeng; Xu, Lanlan; Ji, Chenglong; Yu, Deliang] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Key Lab Coastal Zone Environm Proc,Yantai Inst Co, Yantai 264003, Peoples R China; [Xu, Lanlan; Yu, Deliang] Univ Chinese Acad Sci, Beijing 700049, Peoples R China
英文摘要	Cadmium (Cd) and arsenic (As) are the main metal/metalloid contaminants in the coastal environments of the Bohai Sea, China. In this work, a combined proteomic and metabolomic approach was applied to investigate the biological effects of Cd and As(V) in the early life stage (D-shape larvae) of mussel Mytilus galloprovincialis. Results indicated that Cd was a potential immune toxicant to D-shape larval mussel because of the numerous proteomic responses related to immune system. Additionally, Cd induced oxidative stress, cellular injury and disturbance in nucleic acid metabolism in D-shape larval mussels. However, only two identified proteins were significantly altered in As (V)-treated group, suggesting that D-shape larval mussel was less sensitive to As (V) than to Cd at protein level. These two proteins in response to As (V) suggested that As (V) influenced anti-oxidative system and cell proliferation in D-shape larval mussels. Metabolic responses indicated that Cd and As (V) induced disturbances in osmotic regulation and energy metabolism in D-shape larval mussels via different metabolic pathways. In addition, Cd reduced lipid metabolism as well. This work demonstrated that a combination of proteomics and metabolomics could provide an insightful view in the biological effects of pollutants in mussel M. galloprovincialis at an early life stage. (C) 2016 Published by Elsevier Ltd.
学科主题	Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
研究领域[WOS]	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
关键词[WOS]	LASER-DESORPTION/IONIZATION-TIME ; GENDER-SPECIFIC RESPONSES ; NMR-BASED METABOLOMICS ; BATHYMODIOLUS-AZORICUS ; CELL-CYCLE ; PROTEINS ; GEL ; IDENTIFICATION ; SENSITIVITY ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000387523100061
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/17488]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Key Lab Coastal Zone Environm Proc,Yantai Inst Co, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 700049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Huifeng,Xu, Lanlan,Ji, Chenglong,et al. Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic[J]. FISH & SHELLFISH IMMUNOLOGY,2016,58:514-520.
APA	Wu, Huifeng,Xu, Lanlan,Ji, Chenglong,&Yu, Deliang.(2016).Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic.FISH & SHELLFISH IMMUNOLOGY,58,514-520.
MLA	Wu, Huifeng,et al."Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic".FISH & SHELLFISH IMMUNOLOGY 58(2016):514-520.