Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods
	Wang, Y; Wang, YQ; Wang, WH; Sun, KX; Chen, LX
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016-10-19
卷号	8 期号:41 页码:28105-28115
关键词	gold nanorod SERS tags internal standard core-shell nanoparticle anisotropic property
ISSN号	1944-8244
通讯作者	Sun, KX (reprint author), Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China. ; Wang, YQ ; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. Email:yqwang@yic.ac.cn ; sunkx@ytu.edu.cn ; lxchen@yic.ac.cn
产权排序	[Wang, Yuan; Sun, Kaoxiang] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China; [Wang, Yuan; Wang, Yunqing; Wang, Wenhai; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
英文摘要	Reporter-embedded (RE) tags are a generation of sensitive, stable surface: enhanced Raman scattering (SERB), tags with Raman reporters embedded between gold nano article(NP) core and gold (or silver), shells. Most of the reported RE tags have b-een designed using: Au nanospheres as a seed material. Herein, we investigated the: synthesis and SERS properties of AuNR/reporter/Ag tags by using gold nanorod (AuNR) seeds witk,ariisotropic physical and optical features. Several highlighted points discovered, including the following: (1) The cetyltrimethyl ammonium bromide (CTAB) layer induced the coexistence of chemically and physically adsorbed RaMan reporters on AuNR Conventional washing of the Atil TR-reporter complek with water results in the formation of an "internal external" mixed tag. To obtain a "pure" RE structure, an additional extraction step involving a CTAB solution was essential. (2) The anisotropic distribution of CTAB on AuNR resulted in the preference of the Raman reporters to adsorb to the hotspot at the AuNR tip, which made it a perfect match for improving the SERS signal of the tag. (3) An.anisotropic silver coating occurred with the shell thickness on the AuNThside-growing much faster than the shell"thianess at the tip. This feature ensured that the tag grew to a suitable size with enough silVer for SERS enhancement without shadowing the effective Raman reporters at the tip too much. (4) RE tags showed better in vitro and in vivo signal stabilities compared with their external labeling counterparts. Moreover, a novel pH-sensitive SERS peak test was proposed by using 4-mercaptobenzoic acid as the Raman reporter to verify thin coverage by a silver layer. We believe this tag can be broadly applied for molecular detection and bioimaging, and the proposed preparation and structure verification methods can provide universal guidance in the design of novel RE tags.
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
关键词[WOS]	ENHANCED RAMAN-SCATTERING ; CORE-SHELL NANOPARTICLES ; SILVER NANOPARTICLES ; INTERNAL REFERENCE ; GROWTH METHOD ; NANOSTRUCTURES ; DISSOLUTION ; PARTICLES ; TOXICITY ; LAYER
收录类别	SCI
语种	英语
WOS记录号	WOS:000385992400077
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/17463]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
推荐引用方式 GB/T 7714	Wang, Y,Wang, YQ,Wang, WH,et al. Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(41):28105-28115.
APA	Wang, Y,Wang, YQ,Wang, WH,Sun, KX,&Chen, LX.(2016).Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods.ACS APPLIED MATERIALS & INTERFACES,8(41),28105-28115.
MLA	Wang, Y,et al."Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods".ACS APPLIED MATERIALS & INTERFACES 8.41(2016):28105-28115.