A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 山东省海岸带环境工程技术研究中心

	A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging
	Dong, CH ; Liu, ZY ; Liu, JQ ; Wu, CZ ; Neumann, F ; Wang, HJ ; Schafer-Korting, M ; Kleuser, B ; Chang, J ; Li, WZ
刊名	ADVANCED HEALTHCARE MATERIALS
	2016-09-07
卷号	5 期号:17 页码:2214-2226
关键词	hyperbranched polyglycerol mitochondria targeting NIR ZCIS ZnS QDs photostability tumor theranostics
ISSN号	2192-2640
其他题名	A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging
通讯作者	Chang, J (reprint author), Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Life Sci,Sch Mat Sci & Engn, Tianjin 300072, Peoples R China. ; Ma, N ; Haag, R (reprint author), Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany. ; Ma, N (reprint author), Helmholtz Zentrum Geesthacht, Inst Biomat Res, Kantstr 55, D-14513 Teltow, Germany. Email:jinchang@tju.edu.cn ; nan.ma@hzg.de ; haag@chemie.fu-berlin.de
产权排序	[Dong, Chunhong; Liu, Junqing; Wang, Hanjie; Chang, Jin] Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Life Sci,Sch Mat Sci & Engn, Tianjin 300072, Peoples R China; [Liu, Zhongyun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol Shandong, Yantai 264003, Shandong, Peoples R China; [Wu, Changzhu; Neumann, Falko; Ma, Nan; Haag, Rainer] Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany; [Schaefer-Korting, Monika] Free Univ Berlin, Inst Pharm, Konigin Luise Str 2-4, D-14195 Berlin, Germany; [Kleuser, Burkhard] Univ Potsdam, Inst Ernahrungswissensch, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany; [Li, Wenzhong] Univ Rostock, Reference & Translat Ctr Cardiac Stem Cell Therap, Schillingallee 69, D-18057 Rostock, Germany; [Ma, Nan] Helmholtz Zentrum Geesthacht, Inst Biomat Res, Kantstr 55, D-14513 Teltow, Germany
英文摘要	Considering the critical role of mitochondria in the life and death of cells, non-invasive long-term tracking of mitochondria has attracted considerable interest. However, a high-performance mitochondria-specific labeling probe with high photostability is still lacking. Herein a highly photostable hyperbranched polyglycerol (hPG)-based near-infrared (NIR) quantum dots (QDs) nanoplatform is reported for mitochondria-specific cell imaging. Comprising NIR Zn-Cu-In-S/ZnS QDs as extremely photostable fluorescent labels and alkyl chain (C-12)/triphenylphosphonium (TPP)-functionalized hPG derivatives as protective shell, the tailored QDs@hPG-C-12/TPP nanoprobe with a hydrodynamic diameter of about 65 nm exhibits NIR fluorescence, excellent biocompatibility, good stability, and mitochondria-targeted ability. Cell uptake experiments demonstrate that QDs@hPG-C-12/TPP displays a significantly enhanced uptake in HeLa cells compared to nontargeted QDs@hPG-C-12. Further co-localization study indicates that the probe selectively targets mitochondria. Importantly, compared with commercial deep-red mitochondria dyes, QDs@hPG-C-12/TPP possesses superior photostability under continuous laser irradiation, indicating great potential for long-term mitochondria labeling and tracking. Moreover, drug-loaded QDs@hPG-C-12/TPP display an enhanced tumor cell killing efficacy compared to nontargeted drugs. This work could open the door to the construction of organelle-targeted multifunctional nanoplatforms for precise diagnosis and high-efficient tumor therapy.
学科主题	Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials
研究领域[WOS]	Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
关键词[WOS]	WALLED CARBON NANOTUBES ; CANCER-CELLS ; TARGETED DELIVERY ; QUANTUM DOTS ; POLY(AMIDOAMINE) DENDRIMERS ; DRUG-DELIVERY ; NANOPARTICLE ; THERAPY ; DOXORUBICIN ; NANOPROBE
收录类别	SCI
语种	英语
WOS记录号	WOS:000383776300008
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/17489]
专题	烟台海岸带研究所_山东省海岸带环境工程技术研究中心烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Life Sci,Sch Mat Sci & Engn 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol Shandong 3.Free Univ Berlin, Inst Chem & Biochem 4.Free Univ Berlin, Inst Pharm 5.Univ Potsdam, Inst Ernahrungswissensch 6.Univ Rostock, Reference & Translat Ctr Cardiac Stem Cell Therap 7.Helmholtz Zentrum Geesthacht, Inst Biomat Res
推荐引用方式 GB/T 7714	Dong, CH,Liu, ZY,Liu, JQ,et al. A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(17):2214-2226.
APA	Dong, CH.,Liu, ZY.,Liu, JQ.,Wu, CZ.,Neumann, F.,...&Haag, R.(2016).A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging.ADVANCED HEALTHCARE MATERIALS,5(17),2214-2226.
MLA	Dong, CH,et al."A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging".ADVANCED HEALTHCARE MATERIALS 5.17(2016):2214-2226.