Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice
	Cai, Bingna; Chen, Hua; Sun, Han; Wan, Peng; Sun, Huili; Pan, Jianyu
刊名	FOOD & FUNCTION
	2016
卷号	7 期号:1 页码:390-397
通讯作者	Pan, JY (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresource & Ecol, Guangdong Key Lab Marine Meteria Med, 164 Xingangxi Rd, Guangzhou 510301, Guangdong, Peoples R China.
中文摘要	Chemotherapy is generally accompanied by undesirable side effects, such as immunosuppression and malnutrition, which reduce tolerance to cancer therapies. Prior studies have shown that immunonutrition improves the clinical outcomes of cancer patients. In this study, immunoregulatory polysaccharides from Crassostrea hongkongensis were included in a nutrition formula that was administered to S180 tumor-bearing mice in combination with 5-fluorouracil (5-FU) treatment. The C30-60% fraction of the polysaccharides was characterized as a branched polysaccharide, with a high amount of D-glucose (96.76% of the total) and the highest uronic acid and sulfate groups' content among all of the polysaccharide fractions. The C30-60% polysaccharide fraction showed a maximal proliferative effect on RAW264.7 cells and T lymphocytes at a concentration of 0.0391 mg mL(-1) and 0.0781 mg mL-1, respectively. Moreover, the combination treatment of the C30-60% polysaccharide- based nutrition formula (OPNF) with the administration of 5-FU effectively inhibited the growth of tumors and notably increased the leucocyte and lymphocyte counts in S180 tumor-bearing mice. In addition, a slight increase in the erythrocyte and hemoglobin values was observed in the mice treated with the combination of OPNF and 5-FU. These results suggest that supplementation with a C30-60%-based enteral formula would be beneficial for patients undergoing chemotherapy with 5-FU.
学科主题	Biochemistry & Molecular Biology; Food Science & Technology
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15533]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Cai, Bingna,Chen, Hua,Sun, Han,et al. Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice[J]. FOOD & FUNCTION,2016,7(1):390-397.
APA	Cai, Bingna,Chen, Hua,Sun, Han,Wan, Peng,Sun, Huili,&Pan, Jianyu.(2016).Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice.FOOD & FUNCTION,7(1),390-397.
MLA	Cai, Bingna,et al."Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice".FOOD & FUNCTION 7.1(2016):390-397.