Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea

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	Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea
	Yuan, Weiping; Cheng, Shimiao; Fu, Weitao; Zhao, Min; Li, Xiubao; Cai, Yuepiao; Dong, Jianyong; Huang, Kexin; Gustafson, Kirk R.; Yan, Pengcheng
刊名	JOURNAL OF NATURAL PRODUCTS
	2016
卷号	79 期号:4 页码:1124-1131
通讯作者	Yan, PC (reprint author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China. ; Gustafson, KR ; Yan, PC (reprint author), NCI, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA.
中文摘要	Nineteen metabolites with diverse structures, including the rare pyrroloindoline alkaloid verrupyrroloindoline (1), the unprecedented highly fused benzosesquiterpenoid verrubenzospirolactone (2), the new asteriscane-type sesquiterpenoid 10-deoxocapillosanane D (3), and the two new cyclopentenone derivatives (4S,5S)-4-hydroxy-5-(hydroxymethyl)-2,3-dimethyl-4-pentylcydopent-2-en-1-one (4) and (S)-4-hydroxy-5-methylene-2,3dimethyl-4-pentylcydopent-2-en-1-one (5), were isolated from a South China Sea collection of the soft coral Sinularia verruca. Eleven previously described marine metabolites (7-15, 18, and 19) were also obtained as well as three new EtOH-adduct artifacts (6, 16, and 17). The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 4, 5, and 16 showed protection against the cytopathic effects of HIV-1 infection with EC50 values of 5.8-34 mu M, and 4, 6, and 16 exhibited inhibition against LPS-induced NO production with IC50 values of 24-28 mu M.
学科主题	Plant Sciences; Pharmacology & Pharmacy
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15469]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Yuan, Weiping,Cheng, Shimiao,Fu, Weitao,et al. Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(4):1124-1131.
APA	Yuan, Weiping.,Cheng, Shimiao.,Fu, Weitao.,Zhao, Min.,Li, Xiubao.,...&Yan, Pengcheng.(2016).Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea.JOURNAL OF NATURAL PRODUCTS,79(4),1124-1131.
MLA	Yuan, Weiping,et al."Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea".JOURNAL OF NATURAL PRODUCTS 79.4(2016):1124-1131.