Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum

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	Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
	Zhao, Min; Cheng, Shimiao; Yuan, Weiping; Xi, Yiyuan; Li, Xiubao; Dong, Jianyong; Huang, Kexin; Gustafson, Kirk R.; Yan, Pengcheng
刊名	MARINE DRUGS
	2016
卷号	14 期号:6 页码:111
关键词	soft coral Lobophytum crassum cembrane-based diterpenes NO inhibition
通讯作者	Yan, PC (reprint author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China. ; Gustafson, KR ; Yan, PC (reprint author), NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA.
中文摘要	Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R, 8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8-24 mu M.
学科主题	Pharmacology & Pharmacy
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15405]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Zhao, Min,Cheng, Shimiao,Yuan, Weiping,et al. Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum[J]. MARINE DRUGS,2016,14(6):111.
APA	Zhao, Min.,Cheng, Shimiao.,Yuan, Weiping.,Xi, Yiyuan.,Li, Xiubao.,...&Yan, Pengcheng.(2016).Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum.MARINE DRUGS,14(6),111.
MLA	Zhao, Min,et al."Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum".MARINE DRUGS 14.6(2016):111.