Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium

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	Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium
	Zhao, Bi-Qing; Peng, Shuai; He, Wei-Jun; Liu, Yong-Hong; Wang, Jun-Feng; Zhou, Xiao-Jiang
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2016
卷号	26 期号:20 页码:4996-4999
关键词	Croton tiglium Tiglianes Diterpenoids Antitubercular activity Cytotoxicity
通讯作者	Wang, JF ; Zhou, XJ (reprint author), Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China. ; Zhou, XJ (reprint author), Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China. ; Zhou, XJ (reprint author), Peking Union Med Coll, Beijing 100050, Peoples R China. ; Wang, JF (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China.
英文摘要	Five new tigliane diterpene esters (1-5), highly oxygenated tetracyclic diterpenoid carbon skeleton, together with three known analogues (6-8) were isolated from the leaves of Croton tiglium. Extensive NMR and mass spectroscopic analysis were used to elucidate their structures. Most of the isolated compounds were tested for their cytotoxic and antitubercular activities. Among them, the cytotoxic activities of these tigliane-type diterpenes strongly depend on the species of the tumor cells. Especially, these bioactivity compounds showed strong cytotoxic activities against the K562 cell line, and their inhibition effects were close to the positive control Taxol. Furthermore, compounds 1, 2, 6, and 7 showed potent antitubercular activities with MIC values of 19.5, 20.9, 20.5, and 13.4 mu M, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy; Chemistry
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15274]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Zhao, Bi-Qing,Peng, Shuai,He, Wei-Jun,et al. Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(20):4996-4999.
APA	Zhao, Bi-Qing,Peng, Shuai,He, Wei-Jun,Liu, Yong-Hong,Wang, Jun-Feng,&Zhou, Xiao-Jiang.(2016).Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(20),4996-4999.
MLA	Zhao, Bi-Qing,et al."Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.20(2016):4996-4999.