Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp SCSIO 05705

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	Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp SCSIO 05705
	Wang, Junfeng 1; He, Weijun 1; Qin, Xiaochu 1; Wei, Xiaoyi 1; Tian, Xinpeng 1; Liao, Li 1; Liao, Shengrong 1; Yang, Bin 1; Tu, Zhengchao 1; Chen, Bo 1
刊名	RSC ADVANCES
	2015
卷号	5 期号:84 页码:68736-68742
通讯作者	gale9888@163.com ; yonghongliu@scsio.ac.cn
英文摘要	Three new indolyl diketopiperazine derivatives, penillines A and B (1 and 3), isopenilline A (2), together with seven known alkaloid compounds (E)-3-(1H-imidazole-4-yimethylene)-6-(1H-indl-3-ylmethyl)-2,5-piperazinediol (4), penilloid A (5), meleagrin (6), neoxaline (7), questiomycin A (8), N-(2-hydroxyphenyl)-acetamide (9), 2-benzoxazolinone (10), were isolated from the Antarctic soil-derived fungus Penicillium sp. SCSIO 05705. The new structures of 1-3 were elucidated on the basis of 1D and 2D NMR, mass spectra, CD spectra, and quantum chemical calculations. All the isolated compounds were tested for their antiviral (H1N1 and H3N2), antituberculosis, antibacterial, and cytotoxic activities. Among them, compounds 6-8 had significant in vitro cytotoxicities against the K562, MCF-7, A549, U937, Hela, DU145, HL60, and HT29 cell lines, with IC50 values ranging from 2.73 to 17.7 mu M. In addition, compound 8 showed potent antituberculosis activity with an MIC value of 3.91 mu M, and the inhibition effect was close to the positive control INH (isoniazid, MIC 2.04 mu M). A possible biogenesis pathway for compounds 1-7 was proposed.
学科主题	Chemistry
原文出处	2046-2069
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/14889]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.[Wang, Junfeng 2.He, Weijun 3.Tian, Xinpeng 4.Liao, Shengrong 5.Yang, Bin 6.Wang, Fazuo 7.Liu, Yonghong] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China 8.[He, Weijun 9.Zhou, Xiaojiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 10.[Qin, Xiaochu
推荐引用方式 GB/T 7714	Wang, Junfeng,He, Weijun,Qin, Xiaochu,et al. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp SCSIO 05705[J]. RSC ADVANCES,2015,5(84):68736-68742.
APA	Wang, Junfeng.,He, Weijun.,Qin, Xiaochu.,Wei, Xiaoyi.,Tian, Xinpeng.,...&Liu, Yonghong.(2015).Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp SCSIO 05705.RSC ADVANCES,5(84),68736-68742.
MLA	Wang, Junfeng,et al."Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp SCSIO 05705".RSC ADVANCES 5.84(2015):68736-68742.