Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis
	Gui, Chun 1; Li, Qinglian 1; Mo, Xuhua 1; Qin, Xiangjing 1; Ma, Junying 1; Ju, Jianhua 1
刊名	ORGANIC LETTERS
	2015
卷号	17 期号:3 页码:628-631
通讯作者	jju@scsio.ac.cn
英文摘要	Bioinformatic analyses indicate that TrdC, SlgL, LipX(2), KirHI, and FacHI belong to a group of highly homologous proteins involved in biosynthesis of actinomycete-derived tirandamycin B, streptolydigin, alpha-lipomycin, kirromycin, and factumycin, respectively. However, assignment of their biosynthetic roles has remained elusive. Gene inactivation and complementation, in vitro biochemical assays with synthetic analogues, point mutations, and phylogenetic tree analyses reveal that these proteins represent a new family of Dieckmann cyclases that drive tetramic acid and pyridone scaffold biosynthesis.
学科主题	Chemistry
原文出处	1523-7060
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/14863]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.[Gui, Chun 2.Li, Qinglian 3.Mo, Xuhua 4.Qin, Xiangjing 5.Ma, Junying 6.Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China 7.[Gui, Chun] Univ Chinese Acad Sci, Beijing 110039, Peoples R China 8.[Mo, Xuhua] Qingdao Agr Univ, Sch Life Sci, Shandong Key Lab Appl Mycol, Qingdao 266109, Peoples R China
推荐引用方式 GB/T 7714	Gui, Chun,Li, Qinglian,Mo, Xuhua,et al. Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis[J]. ORGANIC LETTERS,2015,17(3):628-631.
APA	Gui, Chun,Li, Qinglian,Mo, Xuhua,Qin, Xiangjing,Ma, Junying,&Ju, Jianhua.(2015).Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis.ORGANIC LETTERS,17(3),628-631.
MLA	Gui, Chun,et al."Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis".ORGANIC LETTERS 17.3(2015):628-631.