Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds
	Zhu, Yiguang 1; Zhang, Wenjun 1; Chen, Yaolong 1; Yuan, Chengshan 1; Zhang, Haibo 1; Zhang, Guangtao 1; Ma, Liang 1; Zhang, Qingbo 1; Tian, Xinpeng 1; Zhang, Si 1
刊名	CHEMBIOCHEM
	2015
卷号	16 期号:14 页码:2086-2093
关键词	biosynthesis heronamides hydroxylation migrated double bonds polyketides
通讯作者	czhang2006@gmail.com
英文摘要	Heronamides belong to a growing family of beta-amino acid polyketide macrolactams (beta PMs) with an unsaturated side chain. The biosynthetic gene cluster for heronamide F was identified from the deep-sea-derived Streptomyces sp. SCSIO 03032. The involvement of the gene cluster in heronamide biosynthesis was confirmed by the functional characterization of the P450 enzyme HerO as an 8-hydroxylase for tailoring heronamide biosynthesis. The presence of migrated double bonds in the conjugated diene-containing side chain of heronamides was confirmed by feeding experiments with labeled small carboxylic acid molecules. This study is the first demonstration of migrated double bonds in beta PMs with an unsaturated side chain.
学科主题	Biochemistry & Molecular Biology; Pharmacology & Pharmacy
原文出处	1439-4227
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/14769]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.[Zhu, Yiguang 2.Zhang, Wenjun 3.Chen, Yaolong 4.Yuan, Chengshan 5.Zhang, Haibo 6.Zhang, Guangtao 7.Ma, Liang 8.Zhang, Qingbo 9.Tian, Xinpeng 10.Zhang, Si
推荐引用方式 GB/T 7714	Zhu, Yiguang,Zhang, Wenjun,Chen, Yaolong,et al. Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds[J]. CHEMBIOCHEM,2015,16(14):2086-2093.
APA	Zhu, Yiguang.,Zhang, Wenjun.,Chen, Yaolong.,Yuan, Chengshan.,Zhang, Haibo.,...&Zhang, Changsheng.(2015).Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds.CHEMBIOCHEM,16(14),2086-2093.
MLA	Zhu, Yiguang,et al."Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds".CHEMBIOCHEM 16.14(2015):2086-2093.