A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals

CORC > 化学研究所 > 中国科学院化学研究所 > 分子纳米结构与纳米技术实验室

	A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals
	Guan, Mirong 1,2; Li, Jie 1,2; Jia, Qingyan 3; Ge, Jiechao 3; Chen, Daiqin 1,2; Zhou, Yue 1,2; Wang, Pengfei 3; Zou, Toujun 1,2; Zhen, Mingming 1,2; Wang, Chunru 1,2
刊名	ADVANCED HEALTHCARE MATERIALS
	2016-09-07
卷号	5 期号:17 页码:2283-2294
关键词	clearance imaging nanocarbon photodynamic therapy theranostics
英文摘要	Nanocarbons such as carbon nanotubes, graphene derivatives, and carbon nanohorns have illustrated their potential uses as cancer theranostics owing to their intrinsic fluorescence or NIR absorbance as well as superior cargo loading capacity. However, some problems still need to be addressed, such as the fates and long-term toxicology of different nanocarbons in vivo and the improvement of their performance in various biomedical imaging-guided cancer therapy systems. Herein, a versatile and clearable nanocarbon theranostic based on carbon dots (CDs) and gadolinium metallofullerene nanocrystals (GFNCs) is first developed, in which GFNCs enhance the tumor accumulation of CDs, and CDs enhance the relaxivity of GFNCs, leading to an efficient multimodal imaging-guided photodynamic therapy in vivo without obvious long-term toxicity. Furthermore, biochemical analysis reveals that the novel nanotheranostic can harmlessly eliminate from the body in a reasonable period of time after exerting diagnostic and therapeutic function.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35312]
专题	化学研究所_分子纳米结构与纳米技术实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, TIPC, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Guan, Mirong,Li, Jie,Jia, Qingyan,et al. A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(17):2283-2294.
APA	Guan, Mirong.,Li, Jie.,Jia, Qingyan.,Ge, Jiechao.,Chen, Daiqin.,...&Shu, Chunying.(2016).A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals.ADVANCED HEALTHCARE MATERIALS,5(17),2283-2294.
MLA	Guan, Mirong,et al."A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals".ADVANCED HEALTHCARE MATERIALS 5.17(2016):2283-2294.