Large-Scale Persistent Network Reconfiguration Induced by Ketamine in Anesthetized Monkeys: Relevance to Mood Disorders

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	Large-Scale Persistent Network Reconfiguration Induced by Ketamine in Anesthetized Monkeys: Relevance to Mood Disorders
	Lv, Q; Yang, LQ; Li, GL; Wang, ZW; Shen, ZM; Yu, WW; Jiang, QY; Hou, BY; Pu, J; Hu, HL
刊名	BIOLOGICAL PSYCHIATRY
	2016
卷号	79 期号:9 页码:765-775
关键词	STATE FUNCTIONAL CONNECTIVITY TREATMENT-RESISTANT DEPRESSION NMDA RECEPTOR BLOCKADE MAJOR DEPRESSION NONHUMAN-PRIMATES PREFRONTAL CORTEX BRAIN NETWORKS ARCHITECTURE HUMANS ANTIDEPRESSANTS
通讯作者	Wang, Z (reprint author), 320 Yueyang Rd, Shanghai 200031, Peoples R China.,zheng.wang@ion.ac.cn
英文摘要	BACKGROUND: Ketamine is a highly attractive candidate for developing fast-onset antidepressant agents; however, the relevant brain circuits that underlie sustained, efficacious antidepressant effects remain largely unknown. METHODS: We used a holistic scheme combining whole-brain resting-state fMRI and graph theoretical analysis to examine the sustained effects on brain networks after administration of a single dose of ketamine and to identify the brain regions and circuits preferentially targeted by ketamine. Topological differences in functional networks of anesthetized macaque monkeys were compared between ketamine (.5 mg/kg) and saline treatment after 18 hours. RESULTS: We observed persistent global reconfiguration of small-world properties in response to ketamine intake, accompanied by large-scale downregulation of functional connectivity, most prominently in the orbital prefrontal cortex, the subgenual and posterior cingulate cortices, and the nucleus accumbens. Intriguingly, intrinsic connectivity with the medial prefrontal areas in the reward circuits were selectively downregulated. Global and regional regulations of the brain networks precisely opposed the maladaptive alterations in the depressed brain. CONCLUSIONS: Our results demonstrated that local synaptic plasticity triggered by blockade of N-methyl-D-aspartic acid receptors was capable of translating into prolonged network reconfiguration in the distributed corticolimbic-striatal circuit, providing mechanistic insight into developing specific loci or circuit-targeted, long-term therapeutics.
学科主题	Neurosciences; Psychiatry
WOS标题词	Neurosciences & Neurology ; Psychiatry
语种	英语
WOS记录号	WOS:000373674000017
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/4028]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Lv, Q,Yang, LQ,Li, GL,et al. Large-Scale Persistent Network Reconfiguration Induced by Ketamine in Anesthetized Monkeys: Relevance to Mood Disorders[J]. BIOLOGICAL PSYCHIATRY,2016,79(9):765-775.
APA	Lv, Q.,Yang, LQ.,Li, GL.,Wang, ZW.,Shen, ZM.,...&Wang, Z.(2016).Large-Scale Persistent Network Reconfiguration Induced by Ketamine in Anesthetized Monkeys: Relevance to Mood Disorders.BIOLOGICAL PSYCHIATRY,79(9),765-775.
MLA	Lv, Q,et al."Large-Scale Persistent Network Reconfiguration Induced by Ketamine in Anesthetized Monkeys: Relevance to Mood Disorders".BIOLOGICAL PSYCHIATRY 79.9(2016):765-775.