Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting
	Yin, XZ; Wu, L; Li, Y; Guo, T; Li, HY; Xiao, TQ; York, P; Nangia, A; Gui, SY; Zhang, JW
刊名	SCIENTIFIC REPORTS
	2016
卷号	6 期号:-页码:—
关键词	X-RAY MICROTOMOGRAPHY CONTROLLED-RELEASE KINETICS OSMOTIC PUMP TABLETS CRYSTAL-STRUCTURE DENSITY DISTRIBUTIONS MECHANICAL-PROPERTIES COMPACTION PROPERTIES TOMOGRAPHY
ISSN号	2045-2322
通讯作者	Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China. ; Zhang, JW (reprint author), Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China. ; Zhang, JW (reprint author), Anhui Univ Chinese Med, Hefei 230038, Peoples R China.
英文摘要	The deformation behavior of particles under pressure dominates the mechanical properties of solid dosage forms. In this study, the in situ 3D deformation of two polymorphs (I and II) of clopidogrel bisulfate (CLP) was determined to illustrate pressure distribution profiles within the tablet by the deformation of the crystalline particles for the first time. Synchrotron radiation X-ray computed microtomography (SR-mu CT) was utilized to visualize and quantify the morphology of thousands crystalline particles of CLP I and CLP II before and after compression. As a result, the deformation was examined across scale dimensions from microns to the size of the final dosage form. Three dimensional parameters such as volume, sphericity, oblate and prolate of individual particle and distributions were computed and analyzed for quantitative comparison to CLP I and CLP II. The different degrees of deformation under the same compression conditions of CLP I and CLP II were observed and characterized quantitatively. The map of deformation degrees within the tablet illustrated the heterogeneous pressure distribution in various regions of the compacted tablet. In conclusion, the polymorph deformation behaviors demonstrated by SR-p,CT quantitative structure analysis deepen understanding of tableting across dimensions from microns to millimeters for the macrostrcuture of tablet.
收录类别	SCI
语种	英语
WOS记录号	WOS:000370788500001
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/25890]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Yin, XZ,Wu, L,Li, Y,et al. Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting[J]. SCIENTIFIC REPORTS,2016,6(-):—.
APA	Yin, XZ.,Wu, L.,Li, Y.,Guo, T.,Li, HY.,...&Zhang, JW.(2016).Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting.SCIENTIFIC REPORTS,6(-),—.
MLA	Yin, XZ,et al."Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting".SCIENTIFIC REPORTS 6.-(2016):—.