Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex

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	Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex
	Xia, DN; Yu, HZ; Tao, JS; Zeng, JR; Zhu, QL; Zhu, CL; Gan, Y
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2016
卷号	141 期号:-页码:301—310
关键词	SOLID DISPERSIONS ADMINISTERED PACLITAXEL CREMOPHOR-EL ABSORPTION POLY(VINYLPYRROLIDONE) SURFACTANTS DISSOLUTION CELLULOSE PYRENE
ISSN号	0927-7765
通讯作者	Gan, Y (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd,Zhang Jiang Hi Tech Pk, Shanghai 201203, Peoples R China.
英文摘要	Our previous study demonstrated that the retention of drug in the hydrophobic core of Soluplus micelle greatly impeded drug absorption from gastrointestinal tract. Using supersaturated polymeric micelles can improve drug release, however, insufficient maintaining of supersaturation of drug is still unfavorable for drug absorption. Here, we report adding small amount of small molecule, sodium dodecyl sulfate (SDS), to Soluplus solution can form a Soluplus-SDS complex. This complex not only showed a higher solubilization capability for the model drug cyclosporine A (CsA), but also maintained a longer period of and higher supersaturation than was achieved with Soluplus alone. The Soluplus-SDS interactions were characterized by analyzing surface tension, small-angle X-ray scattering (SAXS), fluorescence spectra, and nuclear magnetic resonance spectroscopy. The results demonstrated that the formation of Soluplus-SDS complex via SDS adsorption on hydrophobic segments of Soluplus, which have more hydrophobic domain than that of Soluplus micelle, contributed significantly to the solubilization and stabilization of supersaturated CsA. Using this amphiphilic copolymer-small molecule surfactant system, the cellular uptake and rat in vivo absorption of CsA were more effectively achieved than pure Soluplus. The area under the plasma concentration-time curve (AUC) and the maximal plasma concentration (Cmax) achieved by CsA-loaded Soluplus-SDS complex were 1.58- and 1.8-times higher than the corresponding values for CsA-loaded pure Soluplus, respectively. This study highlighted the benefits of Soluplus-SDS complex for optimizing the solubilization and oral absorption of a drug with low aqueous solubility. (C) 2016 Elsevier B.V. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000374197700035
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/25852]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Xia, DN,Yu, HZ,Tao, JS,et al. Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2016,141(-):301—310.
APA	Xia, DN.,Yu, HZ.,Tao, JS.,Zeng, JR.,Zhu, QL.,...&Gan, Y.(2016).Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex.COLLOIDS AND SURFACES B-BIOINTERFACES,141(-),301—310.
MLA	Xia, DN,et al."Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex".COLLOIDS AND SURFACES B-BIOINTERFACES 141.-(2016):301—310.