Robust Biopolymeric Supramolecular "Host-Guest Macromer" Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration

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	Robust Biopolymeric Supramolecular "Host-Guest Macromer" Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration
	Wei, KC; Zhu, ML; Sun, YX; Xu, JB; Feng, Q; Lin, S; Wu, TY; Xu, J; Tian, F; Xia, J
刊名	MACROMOLECULES
	2016
卷号	49 期号:3 页码:866—875
关键词	HYALURONIC-ACID HYDROGELS MESENCHYMAL STEM-CELLS X-RAY-SCATTERING MECHANICAL-PROPERTIES 3-DIMENSIONAL HYDROGELS BETA-CYCLODEXTRIN BIOMATERIALS ASSEMBLIES CHONDROGENESIS COMPLEXATION
ISSN号	0024-9297
通讯作者	Bian, LM (reprint author), Prince Wales Hosp, Dept Mech & Automat Engn, Div Biomed Engn, Hong Kong, Hong Kong, Peoples R China. ; Bian, LM (reprint author), Prince Wales Hosp, Shun Hing Inst Adv Engn, Hong Kong, Hong Kong, Peoples R China. ; Bian, LM (reprint author), Chinese Univ Hong Kong, Shenzhen Res Inst, Shatin, Hong Kong, Peoples R China. ; Bian, LM (reprint author), China Orthoped Regenerat Med Grp CORMed, Shanghai, Peoples R China.
英文摘要	Biopolymer-based supramolecular hydrogels cross-linked by host guest interactions are usually mechanically weak as shown in "inverted vials" instead of freestanding 3D constructs. Herein, we describe a novel host guest macromer (HGM) approach for preparation of biopolymer-based freestanding supramolecular hydrogels. Host guest macromers are formed by molecular self-assembly between adamantane-functionalized hyaluronic acid (AD(x)HA) guest polymers and monoacrylated beta-cyclodextrins (mono-Ac-beta CD) host monomers. 'Supramolecular hydrogels are readily prepared by UV-induced polymerization of the preassembled host guest macromers. Such hydrogels are soely cross-linked by in situ formed multivalent host guest nanoclusters and show significantly reinforced mechanical properties yet still retain desirable supramolecular features. They can self-heal and be remolded into freestanding 3D constructs which afford effective protection on the encapsulated stem cells during the compression remolding, making them promising carriers for therapeutic cells that can quickly adapt to and integrate with surrounding tissues of the targeted defects. We demonstrate that such hydrogels not only sustain extended release of encapsulated proteinaceous growth factors (TGF-beta 1) but also support chondrogenesis of the human mesenchymal stem cells (hMSCs) and promote cartilage regeneration in a rat model.
收录类别	SCI
语种	英语
WOS记录号	WOS:000370113300016
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/25826]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Wei, KC,Zhu, ML,Sun, YX,et al. Robust Biopolymeric Supramolecular "Host-Guest Macromer" Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration[J]. MACROMOLECULES,2016,49(3):866—875.
APA	Wei, KC.,Zhu, ML.,Sun, YX.,Xu, JB.,Feng, Q.,...&Bian, LM.(2016).Robust Biopolymeric Supramolecular "Host-Guest Macromer" Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration.MACROMOLECULES,49(3),866—875.
MLA	Wei, KC,et al."Robust Biopolymeric Supramolecular "Host-Guest Macromer" Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration".MACROMOLECULES 49.3(2016):866—875.