In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures
	Yin, XZ; Xiao, TQ; Nangia, A; Yang, S; Lu, XL; Li, HY; Shao, Q; He, Y; York, P; Zhang, JW
刊名	SCIENTIFIC REPORTS
	2016
卷号	6 期号:-页码:—
关键词	CLOPIDOGREL BISULFATE CONTROLLED-RELEASE QUANTIFICATION SPECTROSCOPY DIFFRACTION MICROSCOPY IMPURITY KINETICS TABLETS
ISSN号	2045-2322
通讯作者	Zhang, JW (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China.
英文摘要	Polymorphism denotes the existence of more than one crystal structure of a substance, and great practical and theoretical interest for the chemical and pharmaceutical industries. In many cases, it is challenging to produce a pure crystal form and establish a sensitive detection method for the identification of crystal form in a mixture of polymorphs. In this study, an accurate and sensitive method based on synchrotron radiation X-ray computed microtomography (SR-mu CT) was devised to identify the polymorphs of clopidogrel bisulphate (CLP). After 3D reconstruction, crystal particles were extracted and dozens of structural parameters were calculated. Whilst, the particle shapes of the two crystal forms were all irregular, the surface of CLP II was found to be rougher than CLP I. In order to classify the crystal form based on the quantitative morphological property of particles, Volume Bias Percentage based on Surface Smoothing (VBP) was defined and a new method based on VBP was successfully developed, with a total matching rate of 99.91% for 4544 particles and a lowest detectable limit of 1%. More important for the mixtures in solid pharmaceutical formulations, the interference of excipients can be avoided, a feature cannot achieved by other available analytical methods.
收录类别	SCI
语种	英语
WOS记录号	WOS:000374501000002
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/25751]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Yin, XZ,Xiao, TQ,Nangia, A,et al. In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures[J]. SCIENTIFIC REPORTS,2016,6(-):—.
APA	Yin, XZ.,Xiao, TQ.,Nangia, A.,Yang, S.,Lu, XL.,...&Zhang, JW.(2016).In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures.SCIENTIFIC REPORTS,6(-),—.
MLA	Yin, XZ,et al."In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures".SCIENTIFIC REPORTS 6.-(2016):—.