Discovery of biomarkers for oxidative stress based on cellular metabolomics | |
Wang, Ningli1,2,3,4; Wei JT(魏鉴腾)2,3,4; Liu, Yewei1; Pei D(裴栋)2,3,4; Hu, Qingping1; Wang, Yu1; Di DL(邸多隆)2,3,4; Wei JT(魏鉴腾) | |
刊名 | Biomarkers |
2016 | |
卷号 | 21期号:5页码:449-457 |
关键词 | Biomarkers metabolomics oxidative stress |
ISSN号 | 1354-750X |
通讯作者 | Wang, Ningli ; 魏鉴腾 |
英文摘要 | Oxidative stress has a close relationship with various pathologic physiology phenomena and the potential biomarkers of oxidative stress may provide evidence for clinical diagnosis or disease prevention. Metabolomics was employed to identify the potential biomarkers of oxidative stress. High-performance liquid chromatography–diode array detector, mass spectrometry and partial least squares discriminate analysis were used in this study. The 10, 15 and 13 metabolites were considered to discriminate the model group, vitamin E-treated group and l-glutathione-treated group, respectively. Some of them have been identified, namely, malic acid, vitamin C, reduced glutathione and tryptophan. Identification of other potential biomarkers should be conducted and their physiological significance also needs to be elaborated. |
学科主题 | 分析化学与药物化学 |
收录类别 | SCI |
资助信息 | the National Natural Science Foundation of China (21175142;21505143);National High Technology Research and Development Program of China (2014AA022203);Science Foundation of Gansu Province (1308RJYA077) |
语种 | 英语 |
WOS记录号 | WOS:000379348200009 |
内容类型 | 期刊论文 |
源URL | [http://210.77.64.217/handle/362003/20148] |
专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 兰州化学物理研究所_青岛研发中心/青岛市资源化学与新材料研究中心 |
通讯作者 | Wei JT(魏鉴腾) |
作者单位 | 1.Lanzhou Univ, Sch Publ Hlth, Inst Nutr & Food Hyg, 199 Donggang West Rd, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China 4.Ctr Resource Chem & New Mat, Qingdao, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Ningli,Wei JT,Liu, Yewei,et al. Discovery of biomarkers for oxidative stress based on cellular metabolomics[J]. Biomarkers,2016,21(5):449-457. |
APA | Wang, Ningli.,Wei JT.,Liu, Yewei.,Pei D.,Hu, Qingping.,...&魏鉴腾.(2016).Discovery of biomarkers for oxidative stress based on cellular metabolomics.Biomarkers,21(5),449-457. |
MLA | Wang, Ningli,et al."Discovery of biomarkers for oxidative stress based on cellular metabolomics".Biomarkers 21.5(2016):449-457. |
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