Isolation of Secondary Metabolites from the Soil-Derived Fungus Clonostachys rosea YRS-06, a Biological Control Agent, and Evaluation of Antibacterial Activity | |
Zhai, Ming-Ming1; Qi, Feng-Ming1; Li, Jie1; Jiang, Chun-Xiao1; Hou, Yue1; Shi YP(师彦平)2; Di DL(邸多隆)2; Zhang, Ji-Wen3; Wu, Quan-Xiang1,2 | |
刊名 | Journal of Agricultural and Food Chemistry |
2016 | |
卷号 | 64期号:11页码:2298-2306 |
关键词 | Clonostachys rosea YRS-06 antibacterial activity antifungal activity tetrahydrotrichodimer ether dihydrotrichodimer ether TMC-1S1 |
ISSN号 | 0021-8561 |
通讯作者 | Wu, Quan-Xiang |
英文摘要 | The fungus Clonostachys rosea is widely distributed all over the world. The destructive force of this fungus, as a biological control agent, is very strong to lots of plant pathogenic fungi. As part of the ongoing search for antibiotics from fungi obtained from soil samples, the secondary metabolites of C. rosea YRS-06 were investigated. Through efficient bioassay-guided isolation, three new bisorbicillinoids possessing open-ended cage structures, tetrahydrotrichodimer ether (1) and dihydrotrichodimer ether A and B (2 and 3), and 12 known compounds were obtained. Their structures were determined via extensive NMR, HR-ESI-MS, and CD spectroscopic analyses and X-ray diffraction data. Compounds 1–3 are rare bisorbicillinoids with a γ-pyrone moiety. The biological properties of 1–15 were evaluated against six different Gram-positive and Gram-negative bacteria. Bisorbicillinoids, 2–5, and TMC-151 C and E, 14 and 15, showed potent antibacterial activity. |
学科主题 | 分析化学与药物化学 |
收录类别 | SCI |
资助信息 | the National Natural Science Foundation of China (No. 21202075;21272103);the 111 Project;the Scientific Research Foundation for Returned Overseas Students (No. 45);the Scientific Research Ability Training of Undergraduate Students Majoring in Chemistry by the Two Patters Based on the Tutorial System and Top Students Project (J1103307) |
语种 | 英语 |
WOS记录号 | WOS:000372854300014 |
内容类型 | 期刊论文 |
源URL | [http://210.77.64.217/handle/362003/19989] |
专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
作者单位 | 1.State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of China 2.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People’s Republic of China 3.Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China |
推荐引用方式 GB/T 7714 | Zhai, Ming-Ming,Qi, Feng-Ming,Li, Jie,et al. Isolation of Secondary Metabolites from the Soil-Derived Fungus Clonostachys rosea YRS-06, a Biological Control Agent, and Evaluation of Antibacterial Activity[J]. Journal of Agricultural and Food Chemistry,2016,64(11):2298-2306. |
APA | Zhai, Ming-Ming.,Qi, Feng-Ming.,Li, Jie.,Jiang, Chun-Xiao.,Hou, Yue.,...&Wu, Quan-Xiang.(2016).Isolation of Secondary Metabolites from the Soil-Derived Fungus Clonostachys rosea YRS-06, a Biological Control Agent, and Evaluation of Antibacterial Activity.Journal of Agricultural and Food Chemistry,64(11),2298-2306. |
MLA | Zhai, Ming-Ming,et al."Isolation of Secondary Metabolites from the Soil-Derived Fungus Clonostachys rosea YRS-06, a Biological Control Agent, and Evaluation of Antibacterial Activity".Journal of Agricultural and Food Chemistry 64.11(2016):2298-2306. |
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