Enantioselective Primary Amine Catalyzed Aldol-Type Construction of Trifluoromethylated Tertiary Alcohols

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	Enantioselective Primary Amine Catalyzed Aldol-Type Construction of Trifluoromethylated Tertiary Alcohols
	Yang W(杨伟)1; Cui, Yu-Ming 1; Zhou W(周伟)1; Li L(李莉)1; Yang KF(杨科芳)1; Zheng ZJ(郑战江)1; Lu YX(卢一新)2; Xu LW(徐利文)1,3
刊名	SYNLETT
	2014
卷号	25 期号:10 页码:1461-1465
关键词	tertiary alcohol primary amine organofluorine organocatalysis cross-aldol reaction
ISSN号	0936-5214
通讯作者	李莉 ; 徐利文
英文摘要	It was found that the cinchona-derived primary amines and their combined catalyst systems with chiral organic acid or Lewis acid have been successfully applied in the cross-aldol reaction of trifluoromethyl ketones and aliphatic ketones. Excellent yields and good enantioselectivities (up to 89% ee) of the resulting β-trifluoromethyl-β-hydroxy ketones were obtained in the chiral primary amine catalyzed cross-aldol reaction under different conditions, which also led to both enantiomers of the desired products. This study also demonstrated the importance of synergistic effect of chiral organic acid on the primary amine catalysis.
学科主题	物理化学与绿色催化
收录类别	SCI
资助信息	the National Natural Science Foundation of China (NSFC Grant No. 21173064);the Zhejiang Provincial Natural Science Foundation of China (LR14B0300001;LQ12B02004);the Hangzhou Science and Technology Program (20130533B15;20130432B06)
语种	英语
WOS记录号	WOS:000337951000021
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/20342]
专题	兰州化学物理研究所_OSSO国家重点实验室
作者单位	1.College of Material Chemistry and Chemical Engineering, and Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012, P. R. of China 2.Department of Chemistry and Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Republic of Singapore 3.State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 730000, P. R. of China
推荐引用方式 GB/T 7714	Yang W,Cui, Yu-Ming,Zhou W,et al. Enantioselective Primary Amine Catalyzed Aldol-Type Construction of Trifluoromethylated Tertiary Alcohols[J]. SYNLETT,2014,25(10):1461-1465.
APA	Yang W.,Cui, Yu-Ming.,Zhou W.,Li L.,Yang KF.,...&Xu LW.(2014).Enantioselective Primary Amine Catalyzed Aldol-Type Construction of Trifluoromethylated Tertiary Alcohols.SYNLETT,25(10),1461-1465.
MLA	Yang W,et al."Enantioselective Primary Amine Catalyzed Aldol-Type Construction of Trifluoromethylated Tertiary Alcohols".SYNLETT 25.10(2014):1461-1465.