Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer's Disease and Parkinson's Disease

	Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer's Disease and Parkinson's Disease
	Shang, Hong 1,2; Liu, Guiyou 3; Jiang, Yongshuai 4; Fu, Jin 2; Zhang, Benping 2; Song, Rongrong 1; Wang, Weizhi 2
刊名	MOLECULAR NEUROBIOLOGY
	2015-02-01
卷号	51 期号:1 页码:361-369
关键词	Amyotrophic lateral sclerosis Pathway analysis Genome-wide association study Alzheimer's disease Parkinson's disease
英文摘要	Amyotrophic lateral sclerosis (ALS) is the third most common neurodegenerative disease after Alzheimer's disease (AD) and Parkinson's disease (PD). In order to unravel more genetic etiology of ALS, genome-wide association studies (GWAS) have been conducted. However, the newly identified ALS susceptibility loci exert only very small risk effects and cannot fully explain the underlying ALS genetic risk. A large proportion of the heritability of ALS is still to be explained. Recently, pathway analysis of GWAS has been used to investigate the mechanisms of AD and PD. We think that AD or PD risk pathways may also be involved in ALS. In order to confirm this view, we conducted a pathway analysis of two independent ALS GWAS. We identified multiple classifications of the Kyoto Encyclopedia of Genes and Genomes pathways related to metabolism, immune system and diseases, environmental information processing, genetic information processing, cellular processes, and nervous system and neurodegenerative diseases to be the consistent signals in the two ALS GWAS. On the single pathway level, we identified 12 shared pathways. We compared the findings from ALS GWAS with those of previous pathway analyses of AD and PD GWAS. The results further supported the involvement of AD and PD risk pathways in ALS. We believe that our results may advance the understanding of ALS mechanisms and will be very useful for future genetic studies.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	GENOME-WIDE ASSOCIATION ; SUSCEPTIBILITY LOCI ; SPORADIC ALS ; SYSTEM
收录类别	SCI
语种	英语
WOS记录号	WOS:000349006200028
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1431]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Harbin Med Univ, Affiliated Hosp 4, Dept Neurol, Harbin 150086, Heilongjiang, Peoples R China 2.Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, Harbin 150086, Heilongjiang, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China 4.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin 150086, Heilongjiang, Peoples R China
推荐引用方式 GB/T 7714	Shang, Hong,Liu, Guiyou,Jiang, Yongshuai,et al. Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer's Disease and Parkinson's Disease[J]. MOLECULAR NEUROBIOLOGY,2015,51(1):361-369.
APA	Shang, Hong.,Liu, Guiyou.,Jiang, Yongshuai.,Fu, Jin.,Zhang, Benping.,...&Wang, Weizhi.(2015).Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer's Disease and Parkinson's Disease.MOLECULAR NEUROBIOLOGY,51(1),361-369.
MLA	Shang, Hong,et al."Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer's Disease and Parkinson's Disease".MOLECULAR NEUROBIOLOGY 51.1(2015):361-369.