Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOE epsilon 4-negative subgroup

	Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOE epsilon 4-negative subgroup
	Liu, Guiyou 1,2; Zhang, Liangcai 3; Feng, Rennan 4; Liao, Mingzhi 3; Jiang, Yongshuai 3; Chen, Zugen 5; Zhao, Bin 1; Li, Keshen 1
刊名	NEUROBIOLOGY OF AGING
	2013-04-01
卷号	34 期号:4
关键词	Alzheimer's disease Genome-wide association studies PICALM gene Chinese population European ancestry
英文摘要	Recently, the association between PICALM rs3851179 polymorphism and Alzheimer's disease (AD) was investigated in the Chinese population by 3 independent studies. However, both allele and genotype tests failed to reveal any association. The association was identified only in the APOE epsilon 4-negative subgroup. We think that the failure to replicate the association may be because of the relatively small sample size. In this research, we reinvestigated the association using all the samples from these 3 studies (n = 2486, and 1202 cases and 1284 control subjects). We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOE epsilon 4-negative subgroup. Our results indicate that rs3851179 may not be an AD susceptibility locus in the Chinese population and the APOE epsilon 4-negative subgroup. (C) 2013 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Geriatrics & Gerontology ; Neurosciences
研究领域[WOS]	Geriatrics & Gerontology ; Neurosciences & Neurology
关键词[WOS]	GENETIC ASSOCIATION ; VARIANTS ; CR-1 ; LOCI ; CLU
收录类别	SCI
语种	英语
WOS记录号	WOS:000314708000035
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1292]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Guangdong Med Coll, Inst Neurol, Zhanjiang, Guangdong, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin 300308, Peoples R China 3.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 4.Harbin Med Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Harbin, Peoples R China 5.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA
推荐引用方式 GB/T 7714	Liu, Guiyou,Zhang, Liangcai,Feng, Rennan,et al. Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOE epsilon 4-negative subgroup[J]. NEUROBIOLOGY OF AGING,2013,34(4).
APA	Liu, Guiyou.,Zhang, Liangcai.,Feng, Rennan.,Liao, Mingzhi.,Jiang, Yongshuai.,...&Li, Keshen.(2013).Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOE epsilon 4-negative subgroup.NEUROBIOLOGY OF AGING,34(4).
MLA	Liu, Guiyou,et al."Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOE epsilon 4-negative subgroup".NEUROBIOLOGY OF AGING 34.4(2013).