Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum
	Jiang, Wei-Wei 1,2; Liu, Yu-Chen 1; Zhang, Zhi-Jun 1; Liu, Yan-Chun1 ; He, Juan 1; Su, Jia 1; Cheng, Xiao 1; Peng, Li-Yan 1; Shao, Li-Dong 1; Wu, Xing-De 1
刊名	FITOTERAPIA
	2016-03-01
卷号	109 页码:155-161
关键词	Lycopodium obscurum L. Lycopodium alkaloids Obscurumines H-P Anti-AChE activity Immunosuppressive activity
英文摘要	Seven new fawcettimine-type (1-7) and two new lycopodine-type (8 and 9) Lycopodium alkaloids, as well as 10 known compounds, were isolated from the club moss, Lycopodium obscurum L The structures of obscurumines H-P (1-9) were determined based on high-resolution MS and 1D and 2D NMR data. Compounds 1 and 2 include a new skeleton that is formed via the linkage of C-9-N-2', which is "rarely present in Lycopodium alkaloids. The in vitro acetylcholinesterase (AChE) inhibitory activity assay showed that 5 exhibited weak anti-AChE activity with an IC50 value of 81.0 mu M. Compound 8 exhibited inhibition of the secretion of IL-2 in phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) stimulated Jurkat cells, and the IC50 value was 17.2 mu M. (C) 2015 Elsevier B.V. All rights reserved.
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	JAPONICUM
收录类别	SCI
语种	英语
WOS记录号	WOS:000372685400024
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/26188]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Yunnan Agr Univ, Coll Basic Sci & Informat Engn, Kuming 6540201, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Wei-Wei,Liu, Yu-Chen,Zhang, Zhi-Jun,et al. Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum[J]. FITOTERAPIA,2016,109:155-161.
APA	Jiang, Wei-Wei.,Liu, Yu-Chen.,Zhang, Zhi-Jun.,Liu, Yan-Chun.,He, Juan.,...&Zhao, Qin-Shi.(2016).Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum.FITOTERAPIA,109,155-161.
MLA	Jiang, Wei-Wei,et al."Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum".FITOTERAPIA 109(2016):155-161.