Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis
	Zhang, Shi-Jin 1,2; Sun, Wen-Wu2,3 ; Cao, Pei 2; Dong, Xiao-Ping 1; Liu, Ji-Kai 4; Wu, Bin 2,4
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2016-02-05
卷号	81 期号:3 页码:956-968
英文摘要	An efficient C(sp(3))-H bond activation and intramolecular amination reaction via palladium catalysis at the beta-position of carboxyamides to make beta-lactams was described. The investigation of the substrate scope showed that the current reaction conditions favored activation of the beta-methylene group. Short sequences were developed for preparation of various diazabicyclic beta-lactarn compounds with this method as the key step from chiral proline and piperidine derivatives.
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	C-H ACTIVATION ; STRUCTURE-BASED DESIGN ; SIDE-CHAIN SAR ; INHIBITORS ; AMIDATION ; FUNCTIONALIZATION ; HETEROCYCLES ; PRECURSOR ; GAMMA
收录类别	SCI ; IC ; CCR
语种	英语
WOS记录号	WOS:000369771600022
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25957]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shi-Jin,Sun, Wen-Wu,Cao, Pei,et al. Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis[J]. JOURNAL OF ORGANIC CHEMISTRY,2016,81(3):956-968.
APA	Zhang, Shi-Jin,Sun, Wen-Wu,Cao, Pei,Dong, Xiao-Ping,Liu, Ji-Kai,&Wu, Bin.(2016).Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis.JOURNAL OF ORGANIC CHEMISTRY,81(3),956-968.
MLA	Zhang, Shi-Jin,et al."Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis".JOURNAL OF ORGANIC CHEMISTRY 81.3(2016):956-968.