One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction
	Wan, Luo-Sheng 1; Shao, Li-Dong 1; Fu, Liangbing 2; Xu, Jun1,3 ; Zhu, Guo-Lei 1,3; Peng, Xing-Rong 1; Li, Xiao-Nian 1; Li, Yan1 ; Qiu, Ming-Hua1,3
刊名	ORGANIC LETTERS
	2016-02-05
卷号	18 期号:3 页码:496-499
英文摘要	A novel segetane diterpenoid (1) and four jatrophane diterpenoids (2-5) were isolated from an acetone extract of Euphorbia peplus. Due to quantity limitations, we prepared 1 via a Diels-Alder reaction, an approach motivated by this compound's biosynthetic pathway and successfully performed X-ray analysis of 1. Furthermore, in an in vitro activity test, 1 exhibited moderate anti-inflammatory activity, whereas both its precursor (2) and the relevant intermediate (2a, IC50 = 1.56 mu M) exhibited significant anti-inflammatory activity.
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	EUPHORBIA-PARALIAS ; MACROCYCLIC DITERPENES ; BIOLOGICAL EVALUATION ; MULTIDRUG-RESISTANCE ; 1ST INSIGHTS ; DISCOVERY ; MODULATORS ; DENDROIDES ; AGENTS ; LEAD
收录类别	SCI
语种	英语
WOS记录号	WOS:000369771800039
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25951]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China 2.Emory Univ, Dept Chem, 1515 Dickey Dr, Atlanta, GA 30322 USA 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wan, Luo-Sheng,Shao, Li-Dong,Fu, Liangbing,et al. One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction[J]. ORGANIC LETTERS,2016,18(3):496-499.
APA	Wan, Luo-Sheng.,Shao, Li-Dong.,Fu, Liangbing.,Xu, Jun.,Zhu, Guo-Lei.,...&Qiu, Ming-Hua.(2016).One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction.ORGANIC LETTERS,18(3),496-499.
MLA	Wan, Luo-Sheng,et al."One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction".ORGANIC LETTERS 18.3(2016):496-499.