BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus

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	BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus
	Hwang, Dae-Sik 1; Han, Jeonghoon 1; Won, Eun-Ji 1; Kim, Duck-Hyun 1; Jeong, Chang-Bum 1; Hwang, Un-Ki 2; Zhou, Bingsheng 3; Choe, Joonho 4; Lee, Jae-Seong 1
刊名	AQUATIC TOXICOLOGY
	2016-08-01
卷号	177 页码:285-294
关键词	BDE-47 Molting Metamorphosis Ecdysteroid signaling pathway Nuclear receptor Copepod Tigriopus japonicus
ISSN号	0166-445X
英文摘要	2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a persistent organic pollutant (POP) in marine environments. Despite its adverse effects (e.g. developmental retardation) in ecdysozoa, the effects of BDE-47 on transcription of ecdysteroid signaling pathway-involved-nuclear receptor (NR) genes and metamorphosis-related genes have not been examined in copepods. To examine the deleterious effect of BDE-47 on copepod molting and metamorphosis, BDE-47 was exposed to the harpacticoid copepod Tigri-opus japonicus, followed by monitoring developmental retardation and transcriptional alteration of NR genes. The developmental rate was significantly inhibited (P< 0.05) in response to BDE-47 and the agricultural insecticide gamma-hexachlorocyclohexane. Conversely, the ecdysteroid agonist ponasterone A (PoA) led to decreased molting and metamorphosis time (P< 0.05) from the nauplius stage to the adult stage. In particular, expression profiles of all NR genes were the highest at naupliar stages 5-6 except for SVP, FTZ-F1, and HR96 genes. Nuclear receptor USP, HR96, and FTZ-F1 genes also showed significant sex differences (P< 0.05) in gene expression levels over different developmental stages, indicating that these genes may be involved in vitellogenesis. NR gene expression patterns showed significant decreases (P< 0.05)in response to BDE-47 exposure, implying that molting and metamorphosis retardation is likely associated with NR gene expression. In summary, BDE-47 leads to molting and metamorphosis retardation and suppresses transcription of NR genes. This information will be helpful in understanding the molting and metamorphosis delay mechanism in response to BDE-47 exposure. (C) 2016 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Marine & Freshwater Biology ; Toxicology
研究领域[WOS]	Marine & Freshwater Biology ; Toxicology
关键词[WOS]	POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; HARPACTICOID COPEPOD ; ECDYSONE RECEPTOR ; NITOCRA-SPINIPES ; AEDES-AEGYPTI ; DROSOPHILA ; REPRODUCTION ; MOSQUITO ; GROWTH
收录类别	SCI
语种	英语
WOS记录号	WOS:000381529700028
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/28344]
专题	水生生物研究所_藻类生物学及应用研究中心_学位论文
作者单位	1.Sungkyunkwan Univ, Dept Biol Sci, Coll Sci, Suwon 16419, South Korea 2.Natl Fisheries Res & Dev Inst, West Sea Fisheries Res Inst, Marine Ecol Risk Assessment Ctr, Inchon 46083, South Korea 3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 4.Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon 34141, South Korea
推荐引用方式 GB/T 7714	Hwang, Dae-Sik,Han, Jeonghoon,Won, Eun-Ji,et al. BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus[J]. AQUATIC TOXICOLOGY,2016,177:285-294.
APA	Hwang, Dae-Sik.,Han, Jeonghoon.,Won, Eun-Ji.,Kim, Duck-Hyun.,Jeong, Chang-Bum.,...&Lee, Jae-Seong.(2016).BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus.AQUATIC TOXICOLOGY,177,285-294.
MLA	Hwang, Dae-Sik,et al."BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus".AQUATIC TOXICOLOGY 177(2016):285-294.