Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189
	Gao, SS; Li, XM; Williams, K; Proksch, P; Ji, NY; Wang, BG
刊名	JOURNAL OF NATURAL PRODUCTS
	2016-08-01
卷号	79 期号:8 页码:2066-2074
ISSN号	0163-3864
通讯作者	Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China. ; Proksch, P (reprint author), Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany. ; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China. Email:proksch@uni-duesseldorf.de ; nyji@yic.ac.cn ; wangbg@ms.qdio.ac.cn
产权排序	[Gao, Shu-Shan; Li, Xiao-Ming; Wang, Bin-Gui] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China; [Gao, Shu-Shan; Williams, Katherine] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England; [Proksch, Peter] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany; [Ji, Nai-Yun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China
英文摘要	Genome mining of the fungus Mucor irregularis (formerly known as Rhizomucor variabilis) revealed the presence of various gene clusters for secondary metabolite biosynthesis, including several terpene-based clusters. Investigation into the chemical diversity of M. irregularis QEN-189, an endophytic fungus isolated from the fresh inner tissue of the marine mangrove plant Rhizophora stylosa, resulted in the discovery of 20 structurally diverse indole-diterpenes including six new compounds, namely, rhizovarins A-F (1-6). Among them, compounds 1-3 represent the most complex members of the reported indole-diterpenes. The presence of an unusual acetal linked to a hemiketal (1) or a ketal (2 and 3) in an unprecedented 4,6,6,8,5,6,6,6,6-fused indole-diterpene ring system makes them chemically unique. Their structures and absolute configurations were elucidated by spectroscopic analysis, modified Mosher's method, and chemical calculations. Each of the isolated compounds was evaluated for antitumor activity against HL-60 and A-549 cell lines.
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	TREMORGENIC MYCO-TOXINS ; PENICILLIUM-CRUSTOSUM THOM ; STRUCTURE ELUCIDATION ; ABSOLUTE-CONFIGURATION ; ASPERGILLUS-SULPHUREUS ; EMERICELLA-STRIATA ; PENITREM-A ; ALKALOIDS ; PAXILLINE ; INDOLODITERPENES
收录类别	SCI
语种	英语
WOS记录号	WOS:000382274700019
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/17130]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
推荐引用方式 GB/T 7714	Gao, SS,Li, XM,Williams, K,et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(8):2066-2074.
APA	Gao, SS,Li, XM,Williams, K,Proksch, P,Ji, NY,&Wang, BG.(2016).Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189.JOURNAL OF NATURAL PRODUCTS,79(8),2066-2074.
MLA	Gao, SS,et al."Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189".JOURNAL OF NATURAL PRODUCTS 79.8(2016):2066-2074.