Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions

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	Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions
	Wang RW(王若文)1; WANG CHUNMING 1; CAO YANG 1; ZHU ZHI 1; YANG CHAOYONG 1; CHEN JIANZHONG 1; Qing FL(卿凤翎)1; Tan YH(谭蔚泓)1
刊名	Chem. Sci.
	2014
卷号	5 期号:10 页码:4076-4081
其他题名	通过疏水相互作用具备自组装的能力的三氟甲基化核酸类似物
通讯作者	卿凤翎 ; 谭蔚泓
英文摘要	An artificial nucleic acid analogue capable of self-assembly into a duplex merely through hydrophobic interactions is presented. The replacement of Watson-Crick hydrogen bonding with strictly hydrophobic interactions has the potential to confer new properties and facilitate the construction of complex DNA nanodevices. To study how the hydrophobic effect works during the self-assembly of nucleic acid bases, we have designed and synthesized a series of fluorinated nucleic acids (FNA) containing 3,5-bis(trifluoromethyl)benzene (F) and nucleic acids incorporating 3,5-dimethylbenzene (M) as hydrophobic base surrogates. Our experiments illustrate that two single-stranded nucleic acid oligomers could spontaneously organize into a duplex entirely by hydrophobic base pairing if the bases were size-complementary and the intermolecular forces were sufficiently strong.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1039/c4sc01162g
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/38852]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
作者单位	1.湖南大学 2.厦门大学 3.浙江大学 4.中科院上海有机化学研究所
推荐引用方式 GB/T 7714	Wang RW,WANG CHUNMING,CAO YANG,et al. Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions[J]. Chem. Sci.,2014,5(10):4076-4081.
APA	王若文.,WANG CHUNMING.,CAO YANG.,ZHU ZHI.,YANG CHAOYONG.,...&谭蔚泓.(2014).Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions.Chem. Sci.,5(10),4076-4081.
MLA	王若文,et al."Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions".Chem. Sci. 5.10(2014):4076-4081.