Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide

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	Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide
	He W(何伟)1; Qiu HB(邱海波)1; Chen YJ(陈漪洁)1; Yao ZJ(姚祝军)1
刊名	Tetrahedron Lett.
	2014
卷号	55 期号:44 页码:6109-6112
其他题名	Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide
通讯作者	姚祝军
英文摘要	Total synthesis of the originally proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide, has been accomplished by using a [(4+1)+3+3]-peptide fragment-coupling strategy and careful examination and optimization of the multiple dense N-methylated amide-bond formations. The synthetic sample of the proposed coibamide A could not match the natural product in both H-1 and C-13 NMR spectra, but was found to exhibit low micromolar cytotoxicity against the proliferation of three tested cancer cells. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tetlet.2014.09.047
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/38959]
专题	上海有机化学研究所_生命有机化学国家重点实验室
作者单位	1.中科院上海有机化学研究所 2.南京大学
推荐引用方式 GB/T 7714	He W,Qiu HB,Chen YJ,et al. Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide[J]. Tetrahedron Lett.,2014,55(44):6109-6112.
APA	何伟,邱海波,陈漪洁,&姚祝军.(2014).Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide.Tetrahedron Lett.,55(44),6109-6112.
MLA	何伟,et al."Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide".Tetrahedron Lett. 55.44(2014):6109-6112.