Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones

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	Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones
	Chen HY(陈好益)1; Fan GQ(范国钦)1; Li S(李石)1; Mao KB(毛可彬)1; Liu YH(刘元红)1
刊名	Tetrahedron Lett.
	2014
卷号	55 期号:9 页码:1593-1596
其他题名	钛促进的亚胺与氰基亚胺的还原交叉偶联反应: a-氨基酮与1,2-二羰基衍生物的合成
通讯作者	刘元红
英文摘要	The reaction of imines with low-valent titanium species, generated in situ by using Ti((OPr)-Pr-i)(4)/2 c-O5H9-MgCI reagent, affords titanium-imine complex, which can couple with nitriles to provide 2,5-diazatitanacyclopentenes. alpha-Aminoketones are obtained in good yields by quenching the corresponding 2,5-diazatitanacyclopentenes with aqueous HC1 solution. However, when the reaction is first quenched with MeOH in air followed by addition of aqueous HCl solution, 1,2-diketones are formed in good to high yields. (c) 2014 Elsevier Ltd. All rights reserved.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tetlet.2014.01.070
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39046]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	1.中科院上海有机化学研究所 2.沈阳化工大学
推荐引用方式 GB/T 7714	Chen HY,Fan GQ,Li S,et al. Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones[J]. Tetrahedron Lett.,2014,55(9):1593-1596.
APA	陈好益,范国钦,李石,毛可彬,&刘元红.(2014).Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones.Tetrahedron Lett.,55(9),1593-1596.
MLA	陈好益,et al."Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones".Tetrahedron Lett. 55.9(2014):1593-1596.