Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions

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	Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions
	Xu GQ(徐广庆)1; Fu WZ(付文振)1; Liu GD(刘国都)1; SENANAYAKE CHRIS H 1; Tang WJ(汤文军)1
刊名	J. Am. Chem. Soc.
	2014
卷号	136 期号:2 页码:570-573
其他题名	通过不对称Suzuki-Miyaura偶联高效合成Korupensamine A,B, 以及 Michellamine B
通讯作者	汤文军
英文摘要	Efficient asymmetric Suzuki-Miyaura coupling reactions are employed for the first time in total syntheses of chiral biaryl natural products korupensamine A and B in combination with an effective diastereoselective hydrogenation, allowing ultimately a concise and stereoselective synthesis of michellamine B. Chiral monophosphorus ligands L1-3 are effective for the syntheses of a series of functionalized chiral biaryls by asymmetric Suzuki-Miyaura coupling reactions in excellent yields and enantioselectivities (up to 99% ee). The presence of a polar-pi interaction between the highly polarized BOP group and the extended pi system of arylboronic acid coupling partner is believed to be important for the high enantioselectivity.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ja409669r
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39002]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	1.中科院上海有机化学研究所 2.美国勃林格殷格翰制药公司
推荐引用方式 GB/T 7714	Xu GQ,Fu WZ,Liu GD,et al. Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions[J]. J. Am. Chem. Soc.,2014,136(2):570-573.
APA	徐广庆,付文振,刘国都,SENANAYAKE CHRIS H,&汤文军.(2014).Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions.J. Am. Chem. Soc.,136(2),570-573.
MLA	徐广庆,et al."Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions".J. Am. Chem. Soc. 136.2(2014):570-573.