Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression

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	Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression
	Tang, Ming-ming 1,3; Lin, Wen-juan1,2,4 ; Pan, Yu-qin 1,2; Guan, Xi-ting1,3 ; Li, Ying-cong1
刊名	PHYSIOLOGY & BEHAVIOR
	2016-07-01
卷号	161 期号:0 页码:166-173
关键词	Depressive-like behavior Neuroinflammation Neurogenesis Pro-inflammatory cytokine Lipopolysaccharide
ISSN号	0031-9384
英文摘要	Our previous work found that triple central lipopolysaccharide (LPS) administration could induce depressive-like behaviors and increased central pro-inflammatory cytokines mRNA, hippocampal cytokine mRNA in particular. Since several neuroinflammation-associated conditions have been reported to impair neurogenesis, in this study, we further investigated whether the neuroinflammation induced depression would be associated with hippocampal neurogenesis dysfunction. An animal model of depression induced by triple central lipopolysaccharide (LPS) administration was used. In the hippocampus, the neuroinflammatory state evoked by LPS was marked by an increased production of pro-inflammatory cytokines, including interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha. It was found that rats in the neuroinflammatory state exhibited depressive-like behaviors, including reduced saccharin preference and locomotor activity as well as increased immobility time in the tail suspension" test and latency to feed in the novelty suppressed feeding test. Adult hippocampal neurogenesis was concomitantly inhibited, including decreased cell proliferation and newborn cell survival. We also demonstrated that the decreased hippocampal neurogenesis in cell proliferation was significantly correlated with the depressive-like phenotypes of decreased saccharine preference and distance travelled, the core and characteristic symptoms of depression, under neuro inflammation state. These findings provide the first evidence that hippocampal neurogenesis dysfunction is correlated with neuroinflammation-induced depression, which suggests that hippocampal neurogenesis might be one of biological mechanisms underlying depression induced by neruoinflammation. (C) 2016 Elsevier Inc All rights reserved.
WOS标题词	Social Sciences ; Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Psychology, Biological ; Behavioral Sciences
研究领域[WOS]	Psychology ; Behavioral Sciences
关键词[WOS]	LIGHT-DARK CYCLE ; ADULT NEUROGENESIS ; TOLERANCE DEVELOPMENT ; SICKNESS BEHAVIOR ; DENTATE GYRUS ; LEARNED HELPLESSNESS ; CELL-PROLIFERATION ; FORCED SWIM ; RAT-BRAIN ; INFLAMMATION
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000377310500022
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/19946]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Tang, Ming-ming,Lin, Wen-juan,Pan, Yu-qin,et al. Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression[J]. PHYSIOLOGY & BEHAVIOR,2016,161(0):166-173.
APA	Tang, Ming-ming,Lin, Wen-juan,Pan, Yu-qin,Guan, Xi-ting,&Li, Ying-cong.(2016).Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression.PHYSIOLOGY & BEHAVIOR,161(0),166-173.
MLA	Tang, Ming-ming,et al."Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression".PHYSIOLOGY & BEHAVIOR 161.0(2016):166-173.