DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo

	DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo
	Li, Meng-yuan 1,2,4; Lv, Yong-cong 3; Tong, Lin-jiang 2; Peng, Ting 2; Qu, Rong 2,4; Zhang, Tao 4,5; Sun, Yi-ming 2; Chen, Yi 2; Wei, Li-xin 1,4; Geng, Mei-yu 2
刊名	acta pharmacologica sinica
	2016-03-01
卷号	37 期号:3 页码:398-407
关键词	DW10075 VEGF/VEGF receptor inhibitor antitumor angiogenesis U87-MG human glioblastoma
英文摘要	aim: targeting the vegf/vegf receptor (vegfr) pathway has proved to be an effective antiangiogenic approach for cancer treatment. here, we identified 6-((2-((3-acetamidophenyl)amino)pyrimidin-4-yl)oxy)-n-phenyl-1-naphthamide (designated herein as dw10075) as a novel and highly selective inhibitor of vegfrs.
WOS标题词	science & technology ; physical sciences ; life sciences & biomedicine
类目[WOS]	chemistry, multidisciplinary ; pharmacology & pharmacy
研究领域[WOS]	chemistry ; pharmacology & pharmacy
关键词[WOS]	metastatic colorectal-cancer ; renal-cell carcinoma ; angiogenesis inhibitors ; bevacizumab ; axitinib ; targets ; kinases ; potent
收录类别	SCI
语种	英语
WOS记录号	WOS:000371426900012
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/5766]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Pharmacol & Safety Evaluat Key Lab Tibetan Med Qi, Xining 810008, Peoples R China 2.Chinese Acad Sci, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Med Chem, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Tech Univ, Shanghai 200120, Peoples R China
推荐引用方式 GB/T 7714	Li, Meng-yuan,Lv, Yong-cong,Tong, Lin-jiang,et al. DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo[J]. acta pharmacologica sinica,2016,37(3):398-407.
APA	Li, Meng-yuan.,Lv, Yong-cong.,Tong, Lin-jiang.,Peng, Ting.,Qu, Rong.,...&Ding, Jian.(2016).DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.acta pharmacologica sinica,37(3),398-407.
MLA	Li, Meng-yuan,et al."DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo".acta pharmacologica sinica 37.3(2016):398-407.