Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments

	Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments
	Guo, Xinyi 1,2; Xie, Ling 1,2; Zhang, Xuze 3; Ji, Yinfa 1; Chen, Juan 1,2; Pang, Bo 1,2; Xu, Yongtao 4; Qi, Delin 5; Guo, Songchang 1
刊名	integrative zoology
	2016-03-01
卷号	11 期号:2 页码:86-97
关键词	adaptive evolution Fgfr1a scale loss Schizothoracine
英文摘要	fishes harbor a huge resource of phenotypic diversity and are useful for understanding the genetic basis of morphological variation. however, it is difficult to transfer classical genetic mapping to most non-model species. in this study, we performed a comparative sequence analysis of fgfr1a to first interpret the evolution of this candidate scale-loss gene in 15 schizothoracine fishes with various scale phenotypes. while considerable amino acid (aa) substitutions were observed, molecular evolution analysis indicates that the overall coding regions were subject to functional constraint. we also identified extra copies of fgfr1a in 4 scale-loss fishes and detected accelerated evolution in one aa substitution specific to these duplicates. we speculate that fgfr1a had accumulated mutations in the ancestral lineage of scale-loss schizothoracine fishes before experiencing duplication events, which was further followed by the diversification of species. in silico mutation analysis predicted deleterious effects of the mutations while no disruptive molecular mechanism was detected. collectively, our results highlight the important role of fgfr1a gene in the adaptive evolution of schizothoracine fishes during their radiation in the qinghai-tibetan plateau.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	zoology
研究领域[WOS]	zoology
关键词[WOS]	growth-factor-receptor ; scale development ; maximum-likelihood ; evo-devo ; evolution ; zebrafish ; duplication ; inference ; genetics ; medaka
收录类别	SCI
语种	英语
WOS记录号	WOS:000372860800001
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/5698]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, 23 Xinning Rd, Xining 810008, Qinghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qinghai Univ Nationalities, Xining, Peoples R China 4.Qinghai Normal Univ, Xining, Peoples R China 5.Qinghai Univ, Dept Anim Sci, Agr & Anim Husb Coll, 97 Ningzhang Rd, Xining 810016, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Guo, Xinyi,Xie, Ling,Zhang, Xuze,et al. Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments[J]. integrative zoology,2016,11(2):86-97.
APA	Guo, Xinyi.,Xie, Ling.,Zhang, Xuze.,Ji, Yinfa.,Chen, Juan.,...&Guo, Songchang.(2016).Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments.integrative zoology,11(2),86-97.
MLA	Guo, Xinyi,et al."Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments".integrative zoology 11.2(2016):86-97.