Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives

	Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives
	Meng H(孟幻); Xing GM(邢更妹); Sun BY(孙宝云); Zhao F(赵峰); Li W(李炜); Song Y(宋炎); Chen Z(陈真); Yuan H(袁慧); Chen CY(陈春英); Liang XJ(梁兴杰)
刊名	ACS NANO
	2010
卷号	4 期号:5 页码:2773-2783
关键词	Gd@C(82)(OH)(22) fullerene nanoparticle particulate form of medicine tumor angiogenesis
通讯作者	[Meng, Huan ; Xing, Gengmei ; Sun, Baoyun ; Zhao, Feng ; Li, Wei ; Song, Yan ; Chen, Zhen ; Yuan, Hui ; Long, Jing ; Chen, Chunying ; Liang, Xingjie ; Chai, Zhifang ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Meng, Huan ; Xing, Gengmei ; Sun, Baoyun ; Zhao, Feng ; Li, Wei ; Song, Yan ; Chen, Zhen ; Yuan, Hui ; Long, Jing ; Chen, Chunying ; Liang, Xingjie ; Chai, Zhifang ; Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Lei, Hao ; Wang, Xuxia] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnetice Resonance & Atom & Mol Ph, Wuhan 430071, Peoples R China ; [Zhang, Ning ; Zhao, Yuliang] Chinese Acad Sci, Tianjin 300060, Peoples R China ; [Zhang, Ning ; Zhao, Yuliang] Tianjin Canc Hosp, Res Ctr Canc Nanotechnol, Tianjin 300060, Peoples R China
英文摘要	Antiangiogenesis is an effective strategy for cancer treatment because uncontrolled tumor growth depends on tumor angiogenesis and sufficient blood supply. Great progress has been made in developing a "molecular" form of angiogenesis inhibitors; however, the narrow inhibition spectrum limits anticancer efficacy as those inhibitors that usually target a few or even a single angiogenic factor among many angiogenic factors might initially be effective but ultimately lead to the failure of the treatment due to the induction of expression of other angiogenic factors. In this work, we report that with a multiple hydroxyl groups functionalized surface, the Gd@C(82)(OH)(22) fullerenic nanoparticles (f-NPs) are capable of simultaneously downregulating more than 10 angiogenic factors in the mRNA level that is further confirmed at the protein level. After studying this antiangiogenesis activity of the f-NPs by cellular experiment, we further investigated its anticancer efficacy in vivo. A two-week treatment with the f-NPs decreased >40% tumor microvessels density and efficiently lowered the speed of blood supply to tumor tissues by similar to 40%. Efficacy of the treatment using f-NPs in nude mice was comparable to the clinic anticancer drug paclitaxel, while no pronounced side effects were found. These findings indicate that the f-NPs with multiple hydroxyl groups serve as a potent antiangiogenesis inhibitor that can simultaneously target multiple angiogenic factors. We propose that using nanoscale "particulate" itself as a new form of medicine (particulate medicine) may be superior to the traditional "molecular" form of medicine (molecular medicine) in cancer treatment.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science
原文出处	SCI
语种	英语
WOS记录号	WOS:000277976900037
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/239820]
专题	高能物理研究所_院士高能物理研究所_加速器中心高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Meng H,Xing GM,Sun BY,et al. Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives[J]. ACS NANO,2010,4(5):2773-2783.
APA	孟幻.,邢更妹.,孙宝云.,赵峰.,李炜.,...&Zhao, YL.(2010).Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives.ACS NANO,4(5),2773-2783.
MLA	孟幻,et al."Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives".ACS NANO 4.5(2010):2773-2783.