Quantification of Proteins by Use of ICP-MS

	Quantification of Proteins by Use of ICP-MS
	Zheng LN(郑令娜); Wang M(王萌); Wang HJ(王华建); Feng WY(丰伟悦); Chai ZF(柴之芳); Zheng, LN; Wang, M; Wang, HJ; Li, JJ; Feng, WY
刊名	PROGRESS IN CHEMISTRY
	2010
卷号	22 期号:11 页码:2199-2206
关键词	ICP-MS ESI-MS MALDI-MS protein quantification element labeling immunoassay
通讯作者	[Zheng Lingna ; Wang Meng ; Wang Huajian ; Feng Weiyue ; Chai Zhifang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zheng Lingna ; Li Jianjun] Zhengzhou Univ, Dept Chem, Zhengzhou 450001, Peoples R China
英文摘要	Proteomics has become one of the most active fields in life sciences The study of biological functions of proteins not only relies on high-throughput identification of proteins, but also on quantitative analysis of the dynamic proteins that is termed quantitative proteomics Quantitative proteomics is anticipated to provide new insights Into biological functions, facilitate the identification of prognostic disease markers and contribute to discovery of proteins as therapeutic targets The available methods for quantitative proteomics are mainly based on the isotope tagging combined with biological mass spectrometry (such as electrospray ionization mass spectrometry (ESI-MS), and matrix assisted laser desorption ionization mass spectrometry (MALDI-MS)) Recently inductively coupled plasma-mass spectrometry (ICP-MS), as an attractive complement to ESI-MS and MALDI-MS, has played an increasing role in protein quantification, especially in absolute protein quantification ICP-MS is an ideal instrument for determination of trace elements in biomolecules because of its unique advantages, such as high sensitivity, wide dynamic range, and minimal matrix effects This review will selectively discuss the recent advances of ICP-MS based techniques and their applications in protein quantification and immunoassay
学科主题	Chemistry
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
原文出处	SCI
语种	英语
WOS记录号	WOS:000284860900014
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/239683]
专题	高能物理研究所_院士高能物理研究所_加速器中心高能物理研究所_多学科研究中心中国科学院高能物理研究所_中国散裂中子源
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zheng LN,Wang M,Wang HJ,et al. Quantification of Proteins by Use of ICP-MS[J]. PROGRESS IN CHEMISTRY,2010,22(11):2199-2206.
APA	郑令娜.,王萌.,王华建.,丰伟悦.,柴之芳.,...&Chai, ZF.(2010).Quantification of Proteins by Use of ICP-MS.PROGRESS IN CHEMISTRY,22(11),2199-2206.
MLA	郑令娜,et al."Quantification of Proteins by Use of ICP-MS".PROGRESS IN CHEMISTRY 22.11(2010):2199-2206.