Tissue contents and subcellular distribution of chromium and other trace metals in experimental diabetic rats after intravenous injection of Cr 50-enriched stable isotopic tracer solution

	Tissue contents and subcellular distribution of chromium and other trace metals in experimental diabetic rats after intravenous injection of Cr 50-enriched stable isotopic tracer solution
	Feng WY(丰伟悦); Qian QF(钱琴芳); Ding WJ(丁万见); Chai ZF(柴之芳); Feng, WY; Qian, QF; Ding, WJ; Chai, ZF
刊名	METABOLISM-CLINICAL AND EXPERIMENTAL
	2001
卷号	50 期号:10 页码:1168-1174
通讯作者	Chinese Acad Sci, Inst High Energy Phys, Beijing 100080, Peoples R China ; Chinese Acad Sci, Lab Nucl Analyt Techniques, Beijing 100080, Peoples R China
英文摘要	In order to study the metabolism of essential trace elements in diabetics, we studied alloxan-diabetic rats for the distribution patterns of chromium (Cr), cobalt (Co), iron (Fe), selenium (Se), and zinc (Zn) in the liver, kidney, pancreas, and testes, as well as in the organ subcellular fractions. Normal rats were used as controls. Cr 50-enriched stable isotopic tracer solution was given by intravenous injection to avoid the difficulties of estimation of Cr status. Our data show that the concentrations of Zn in liver and kidney, of Co, Fe, and Zn in pancreas, and of Fe and Zn in testes of the diabetic rats were significantly higher than in the control rats. Nevertheless, the concentrations of Cr in pancreas, Fe in kidney, and Cr and Se in testes of the diabetic rats were significantly lower than in the controls. Furthermore, we observed significant alterations of element concentrations in subcellular fractions of various organs in the diabetic rats. These results suggest that changing hormone levels may interfere with the accumulation of some trace elements both in the organs and in the subcellular fractions of rats. Copyright (C) 2001 by WB. Saunders Company.
学科主题	Endocrinology & Metabolism
类目[WOS]	Endocrinology & Metabolism
研究领域[WOS]	Endocrinology & Metabolism
原文出处	SCI
语种	英语
WOS记录号	WOS:000171538800008
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/239135]
专题	高能物理研究所_院士
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Feng WY,Qian QF,Ding WJ,et al. Tissue contents and subcellular distribution of chromium and other trace metals in experimental diabetic rats after intravenous injection of Cr 50-enriched stable isotopic tracer solution[J]. METABOLISM-CLINICAL AND EXPERIMENTAL,2001,50(10):1168-1174.
APA	丰伟悦.,钱琴芳.,丁万见.,柴之芳.,Feng, WY.,...&Chai, ZF.(2001).Tissue contents and subcellular distribution of chromium and other trace metals in experimental diabetic rats after intravenous injection of Cr 50-enriched stable isotopic tracer solution.METABOLISM-CLINICAL AND EXPERIMENTAL,50(10),1168-1174.
MLA	丰伟悦,et al."Tissue contents and subcellular distribution of chromium and other trace metals in experimental diabetic rats after intravenous injection of Cr 50-enriched stable isotopic tracer solution".METABOLISM-CLINICAL AND EXPERIMENTAL 50.10(2001):1168-1174.