Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles

	Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles
	Wang B(汪冰); Wang Y(王云); Feng WY(丰伟悦); Zhu MT(朱墨桃); Wang M(王萌); Ou YH(欧阳宏); Wang HJ(王华建); Li M(李明); Zhao YL(赵宇亮); Chai ZF(柴之芳)
刊名	CHEMIA ANALITYCZNA
	2008
卷号	53 期号:6 页码:927-942
关键词	Fe2O3 nanoparticles Trace metals in mice brain Cu, Zn ICP-MS NAA
通讯作者	[Wang, Bing ; Wang, Yun ; Feng, Weiyue ; Zhu, Motao ; Wang, Meng ; Ouyang, Hong ; Wang, Huajian ; Li, Ming ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Wang, Bing ; Wang, Yun ; Feng, Weiyue ; Zhu, Motao ; Wang, Meng ; Ouyang, Hong ; Wang, Huajian ; Li, Ming ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Wang, Yun ; Zhu, Motao ; Wang, Meng ; Wang, Huajian ; Li, Ming] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
英文摘要	Trace metals in the brain play an important role in the Function of central nervous system (CNS). The objective of this work is to investigate the effects of intranasal exposure Of nano- and submicron-sized Fe2O3 particles on the homeostasis of trace metals ill the brain. After a single intranasal instillation of nano- and submicron-sized Fe2O3 particles, the contents of Fe, Cu and Zn in the sub-brain regions were determined in the time course from 4 h till to the 30 day post-exposure. Our results indicated that the imbalance of trace metals in the sub-brain regions of mice was induced by the two sizes of Fe2O3 particles. The more significant accumulation of Fe in the brain was found in the nano-Fe2O3 treated mice than in the submicron-Fe2O3 treated ones; meanwhile, similar alterations of Zn contents in the brain were observed as well. A strong positive correlation between Fe and Zn levels in the olfactory bulb of nano-Fe2O3 instilled mice and in the hippocampus and cerebral cortex of submicron-Fe2O3 instilled mice were found. This is the first trial to investigate the disturbance of trace metals in the brain after exposure to Fe2O3 nanoparticles. These results state that much attention should be paid to the potential impact of inhaled Fe2O3 nanoparticles on the CNS.
学科主题	Chemistry
类目[WOS]	Chemistry, Analytical
研究领域[WOS]	Chemistry
原文出处	SCI
语种	英语
WOS记录号	WOS:000262975600015
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/238752]
专题	高能物理研究所_院士高能物理研究所_加速器中心高能物理研究所_粒子天体物理中心高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang B,Wang Y,Feng WY,et al. Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles[J]. CHEMIA ANALITYCZNA,2008,53(6):927-942.
APA	汪冰.,王云.,丰伟悦.,朱墨桃.,王萌.,...&Chai, ZF.(2008).Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles.CHEMIA ANALITYCZNA,53(6),927-942.
MLA	汪冰,et al."Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles".CHEMIA ANALITYCZNA 53.6(2008):927-942.