Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis

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	Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis
	Liang, XJ; Meng H(孟幻); Meng J(孟洁); Zhao YL(赵宇亮); Gao XY(高学云); Sun BY(孙宝云); Xing GM(邢更妹); Meng, H; Wang, YZ; He, HY
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2010
卷号	107 期号:16 页码:7449-7454
关键词	drug resistance nanomedicine nanoimaging chemotherapy nanopharmaceutical
通讯作者	[Liang, Xing-Jie ; Wang, Yingze ; He, Haiyong ; Meng, Jie ; Lu, Juan ; Chen, Chunying ; Wu, Yan] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Meng, Huan ; Meng, Jie ; Zhao, Yuliang ; Gao, Xueyun ; Sun, Baoyun ; Xing, Genmei] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Wang, Paul C.] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA ; [Shen, Dingwu ; Gottesman, Michael M.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA ; [Yin, Jun-jie] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA ; [Jia, Lee] NCI, Dev Therapeut Program, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA
英文摘要	Cisplatin is a chemotherapeutic drug commonly used in clinics. However, acquired resistance confines its application in chemotherapeutics. To overcome the acquired resistance to cisplatin, it is reasoned, based on our previous findings of mediation of cellular responses by [Gd@C(82)(OH)(22)](n) nanoparticles, that [Gd@C(82)(OH)(22)](n) may reverse tumor resistance to cisplatin by reactivating the impaired endocytosis of cisplatin-resistant human prostate cancer (CP-r) cells. Here we report that exposure of the CP-r PC-3-luc cells to cisplatin in the presence of nontoxic [Gd@C(82)(OH)(22)](n) not only decreased the number of surviving CP-r cells but also inhibited growth of the CP-r tumors in athymic nude mice as measured by both optical and MRI. Labeling the CP-r PC-3 cells with transferrin, an endocytotic marker, demonstrated that pretreatment of the CP-r PC-3-luc cells with [Gd@C(82)(OH)(22)](n) enhanced intracellular accumulation of cisplatin and formation of cisplatin-DNA adducts by restoring the defective endocytosis of the CP-r cancer cells. The results suggest that [Gd@C(82)(OH)(22)](n) nanoparticles overcome tumor resistance to cisplatin by increasing its intracellular accumulation through the mechanism of restoring defective endocytosis. The technology can be extended to other challenges related to multidrug resistance often found in cancer treatments.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
原文出处	SCI
语种	英语
WOS记录号	WOS:000276892300062
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/240118]
专题	中国科学院高能物理研究所_中国散裂中子源高能物理研究所_实验物理中心高能物理研究所_加速器中心高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liang, XJ,Meng H,Meng J,et al. Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(16):7449-7454.
APA	Liang, XJ.,孟幻.,孟洁.,赵宇亮.,高学云.,...&Jia, L.(2010).Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(16),7449-7454.
MLA	Liang, XJ,et al."Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.16(2010):7449-7454.