Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases

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	Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases
	Ma, L; Lu, LP; Zhu, ML; Wang, QM; Li, Y; Xing, S; Fu, XQ; Gao, ZQ; Dong, YH; Gao ZQ(高增强)
刊名	DALTON TRANSACTIONS
	2011
卷号	40 期号:24 页码:6532-6540
通讯作者	[Ma, Ling ; Lu, Liping ; Zhu, Miaoli ; Wang, Qingming ; Li, Ying] Shanxi Univ, Educ Minist, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Taiyuan 030006, Shanxi, Peoples R China ; [Xing, Shu ; Fu, Xueqi] Jilin Univ, Coll Life Sci, Edmond H Fischer Signal Transduct Lab, Changchun 130023, Peoples R China ; [Zhu, Miaoli ; Gao, Zengqiang ; Dong, Yuhui] Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China
英文摘要	Six copper complexes of Schiff base ligands containing 3,5-substituted-4-salicylideneamino-3,5-dimethyl-1,2,4-triazole have been synthesized and well characterized. The structures of complexes 1 and 2 were determined by X-ray crystal analysis. Fluorescence and potentiometric study indicated that in the physiological pH range, one ligand was dissociated from the complexes to form 1 : 1 mononucleus copper complexes. The complexes potently inhibit protein tyrosine phosphatase 1B (PTP1B), T-cell protein tyrosine phosphatase (TCPTP), megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) and Src homology phosphatase 1 (SHP-1) with 3-4 fold selectivity against PTP1B over TCPTP and PTP-MEG2, and 3-9 fold over SHP-1, but display almost no inhibition against Src homology phosphatase 2 (SHP-2). Complex 1 inhibits PTP1B with a competitive model with K-i of 30 nM. Substitution with small groups at the phenyl of the ligand does not obviously influence the inhibitory ability of the complexes.
学科主题	Chemistry
类目[WOS]	Chemistry, Inorganic & Nuclear
研究领域[WOS]	Chemistry
原文出处	SCI
语种	英语
WOS记录号	WOS:000291385700029
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/240081]
专题	高能物理研究所_核技术应用研究中心高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Ma, L,Lu, LP,Zhu, ML,et al. Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases[J]. DALTON TRANSACTIONS,2011,40(24):6532-6540.
APA	Ma, L.,Lu, LP.,Zhu, ML.,Wang, QM.,Li, Y.,...&董宇辉.(2011).Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases.DALTON TRANSACTIONS,40(24),6532-6540.
MLA	Ma, L,et al."Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases".DALTON TRANSACTIONS 40.24(2011):6532-6540.